Nature Reviews Disease Primers, 2018 Burkholderia pseudomallei is a Gram-negative environmental bacterium and the aetiological agent of melioidosis, a life-threatening infection that is estimated to account for ∼89,000 deaths per year worldwide. Diabetes mellitus is a major risk factor for melioidosis, and the global diabetes pandemic could increase the number of fatalities caused by ...
Wiersinga, W. Joost +6 more
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Structure analysis of biologically important prokaryotic glycopolymers [PDF]
, 2013 Of the many post-translational modifications organisms can undertake, glycosylation is the most prevalent and the most diverse. The research in this thesis focuses on the structural characterisation of glycosylation in two classes of glycopolymer (
Ventura, Valeria Victoria +1 more
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Melioidosis, Northeastern Brazil [PDF]
, 2005 Melioidosis is a fatal bacterial infection found in many parts of the tropical belt, particularly in Southeast Asia and northern Australia. Sporadic cases of the disease have been reported previously in Central and South America.
Rolim, D.B. +9 more
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Type three secretion system-mediated escape of Burkholderia pseudomallei into the host cytosol is critical for the activation of NFκB. [PDF]
, 2014 BackgroundBurkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease endemic in Southeast Asia and Northern Australia.
Chen, Isabelle Gek Joo +9 more
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Current Opinion in Infectious Diseases, 2002 Melioidosis is an important public health problem in some regions, and a potential bioweapon. Recent reports confirm that it is endemic in China, Taiwan and Laos, but the true incidence in most countries is unknown, and the ecology poorly understood. Potable water was the source of two recent outbreaks.
I, Leeuwenburgh +4 more
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A Machine Learning-Based Raman Spectroscopic Assay for the Identification of Burkholderia mallei and Related Species [PDF]
, 2019 Burkholderia (B.) mallei, the causative agent of glanders, and B. pseudomallei, the causative agent of melioidosis in humans and animals, are genetically closely related. The high infectious potential of both organisms, their serological cross-reactivity,
Bocklitz, Thomas +8 more
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An international, multicentre evaluation and description of Burkholderia pseudomallei infection in cystic fibrosis [PDF]
, 2015 BACKGROUND: Several cases of Burkholderia pseudomallei infection in CF have been previously reported. We aimed to identify all cases globally, risk factors for acquisition, clinical consequences, and optimal treatment strategies.
Bell, SC +3 more
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Whole-genome sequencing of a quarter-century melioidosis outbreak in temperate Australia uncovers a region of low-prevalence endemicity [PDF]
, 2016 This study was funded by the National Health and Medical Research Council via awards 1046812 and 1098337, and the Wellcome Trust Sanger Institute via award 098051. S.J.P.
Buller, Nicky +8 more
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Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis [PDF]
, 2016 © 2016 by the authors; licensee MDPI, Basel, Switzerland.To identify potential biomarkers for improving diagnosis of melioidosis, we compared plasma metabolome profiles of melioidosis patients compared to patients with other bacteremia and controls ...
Chan, JFW +16 more
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Development of a prototype Lateral Flow Immunoassay (LFI) for the rapid diagnosis of melioidosis [PDF]
, 2014 Burkholderia pseudomallei is a soil-dwelling bacterium and the causative agent of melioidosis. Isolation of B. pseudomallei from clinical samples is the “gold standard” for the diagnosis of melioidosis; results can take 3–7 days to ...
AuCoin, David +17 more
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