Results 91 to 100 of about 13,389 (206)

Acanthamoeba castellanii–Mediated Reduction of Interleukin‐1β Secretion and Its Association With Macrophage Autophagy

Scientifica, Volume 2025, Issue 1, 2025.
Noncanonical autophagy including unconventional protein secretion has been extensively studied. Our work focused on a leaderless IL‐1β protein secretion from human macrophage in response to Acanthamoeba castellanii components, Acanthamoeba culture supernatant (CS) and cell lysate (CL), as well as its association with macrophage autophagy.
Rachasak Boonhok, Wilaiwan Senghoi, Suthinee Sangkanu, Chooi Ling Lim, Matsayapan Pudla, Maria de Lourdes Pereira, Polrat Wilairatana, Tooba Mahboob, Md. Atiar Rahman, Pongsak Utaisincharoen, Poonsit Hiransai, Veeranoot Nissapatorn, Simone Carradori   +12 more
wiley   +1 more source

The characteristics and clinical course of patients with melioidosis and cancer.

PLoS Neglected Tropical Diseases
BackgroundPatients with an active cancer are more likely to develop melioidosis, but the characteristics and clinical course of melioidosis in patients with cancer have not been examined in detail.
Tej Shukla, Simon Smith, Kristoffer Johnstone, Patrick Donald, Josh Hanson   +4 more
doaj   +1 more source

Penicillium‐Derived Inhibitors of Plasmodium falciparum Lactate Dehydrogenase (PfLDH): A Computational Approach for Novel Antimalarial Therapy Development

Scientifica, Volume 2025, Issue 1, 2025.
Malaria remains a major global health challenge, necessitating the discovery of novel therapeutic agents. This study investigates secondary metabolites from Penicillium spp. as potential inhibitors of Plasmodium falciparum lactate dehydrogenase (PfLDH), a critical enzyme in the parasite’s glycolytic pathway.
Imran Sama-ae, Pimthip Muengthongon, Azeezah Tohlaeh, Watcharaphon Rukhachan, Pawika Kiattikul, Fathiyah Samaeng, Aritsara Mitklin, Md. Atiar Rahman, Aman Tedasen, Pattamaporn Kwankaew, Manas Kotepui, Anirut Kepan, Simone Carradori   +12 more
wiley   +1 more source

Clinical and Imaging Findings of Musculoskeletal Melioidosis in the Right Hip: A Case Report

대한영상의학회지, 2018
Melioidosis is an infectious disease caused by a Gram-negative bacterium thought to be caused Burkholderia pseudomallei. This disease is endemic in tropical regions, but is not endemic and is rarely encountered in Korea.
Myung Hyun Kim, Tong Jin Chun
doaj   +1 more source

Burkholderia pseudomallei Sequence Type 46 Transmission from Asia to Australia

Emerging Infectious Diseases
Melioidosis is caused by the environmental pathogen Burkholderia pseudomallei. Among 1,331 patients with melioidosis during 1989–2023 in the Darwin Prospective Melioidosis Study in Australia, we identified 6 locally acquired cases caused by B ...
Ella M. Meumann, Mirjam Kaestli, Jessica R. Webb, Vanessa Rigas, Celeste Woerle, Mark Mayo, Bart J. Currie   +6 more
doaj   +1 more source

Exonic sequencing identifies TLR1 genetic variation associated with mortality in Thais with melioidosis

Emerging Microbes and Infections, 2019
Melioidosis, an infectious disease caused by the bacterium Burkholderia pseudomallei, is a common cause of sepsis in Southeast Asia. We investigated whether novel TLR1 coding variants are associated with outcome in Thai patients with melioidosis.
Shelton W. Wright, Mary J. Emond, Lara Lovelace-Macon, Deirdre Ducken, James Kashima, Viriya Hantrakun, Wirongrong Chierakul, Prapit Teparrukkul, Narisara Chantratita, Direk Limmathurotsakul, T. Eoin West   +10 more
doaj   +1 more source

Melioidosis, Singapore, 2003–2014

Emerging Infectious Diseases, 2018
In contrast with northern Australia and Thailand, in Singapore the incidence of melioidosis and co-incidence of melioidosis and pneumonia have declined. Burkholderia pseudomallei deep abscesses increased 20.4% during 2003–2014.
Long Pang, Patrick N.A. Harris, Rachel L. Seiler, Peng Lim Ooi, Jeffrey Cutter, Kee Tai Goh, Alex R. Cook, Dale Fisher, Louis Yi Ann Chai   +8 more
doaj   +1 more source

Clinical Implications of High Melioidosis Serology Indirect Haemagglutination Assay Titre: A 20-Year Retrospective Study from the Top End of the Northern Territory, Australia

Pathogens
Melioidosis, an infection with the bacterium Burkholderia pseudomallei, is highly endemic in the Top End of the Northern Territory of Australia. The indirect haemagglutination assay (IHA) is the most widely used serology test globally, but it is not ...
Cassandra Ho, Kevin Freeman, Celeste Woerle, Mila Mahoney, Mark Mayo, Robert W. Baird, Ella M. Meumann, Bart J. Currie   +7 more
doaj   +1 more source

Development and evaluation of a multiplex serodiagnostic bead assay (BurkPx) for accurate melioidosis diagnosis

PLoS Neglected Tropical Diseases, 2023
Burkholderia pseudomallei, the causative agent of melioidosis, is a gram-negative soil bacterium well recognized in Southeast Asia and northern Australia. However, wider and expanding global distribution of B. pseudomallei has been elucidated.
Erik W. Settles, Derek Sonderegger, Austin B. Shannon, Kimberly R. Celona, Rachel Lederer, Jinhee Yi, Courtney Seavey, Kyle Headley, Mimi Mbegbu, Maxx Harvey, Mitch Keener, Chris Allender, Heidie Hornstra, Fernando P. Monroy, Celeste Woerle, Vanessa Theobald, Mark Mayo, Bart J. Currie, Paul Keim   +18 more
doaj  

Geographic Clusters and Epidemiological Patterns of Melioidosis in Northern Malaysia: A Retrospective Cohort Study From 2014–2019 [PDF]

BIO Web of Conferences
Melioidosis is an infectious disease caused by Burkholderia pseudomallei. It is native to Southeast Asia and Northern Australia and not notifiable to the public and even among clinicians in most countries where it is endemic.
Mardhiah Kamaruddin, Nafi Mohd Noor Azam, Mohd Shafie Siti Nurhafizah, Saharudin Muhammad Azri, Sobari Muhammad Safwan, Nor-Azlina Rosdi, Nursyahiyatul-Anis Othman   +6 more
doaj   +1 more source