Results 71 to 80 of about 13,389 (206)

Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway [PDF]

, 2015
© 2015 Lau et al.Background: Burkholderia pseudomallei is an emerging pathogen that causes melioidosis, a serious and potentially fatal disease which requires prolonged antibiotics to prevent relapse.
Chow, WN, Curreem, SOT, Hui, SW, Lam, CW, Lau, CY, Lau, SKP, Lee, KC, Martelli, P, Sridhar, S, Wong, SCY, Woo, PCY, Yuen, KY   +11 more
core   +1 more source

Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon

Advanced Therapeutics, Volume 8, Issue 4, April 2025.
Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap, Pankaj R. Khuspe, Sagar R. Pardeshi, Md Jasim Uddin, Ushasi Das, Navnath T. Hatvate, Satish Rojekar, Prabhanjan Giram, Mohammad Khalid, Yahya E. Choonara, Md. Faiyazuddin   +10 more
wiley   +1 more source

Prolonged Fever in Children: An Inpatient Diagnostic Framework for Infections in Australia

Journal of Paediatrics and Child Health, Volume 61, Issue 4, Page 532-539, April 2025.
ABSTRACT There are many causes of fever in children, ranging from common and self‐limiting to serious and life threatening. Careful assessment of children with prolonged fever without an obvious or identified source requires detailed history and examination with consideration of infections unique to the specific geographical region and individual ...
Heshani Rupasinghe, Clare Nourse, Jennifer Robson, Angela Berkhout   +3 more
wiley   +1 more source

Burkholderia pseudomallei Isolates from Sarawak, Malaysian Borneo, Are Predominantly Susceptible to Aminoglycosides and Macrolides [PDF]

, 2014
Melioidosis is a potentially fatal disease caused by the saprophytic bacterium Burkholderia pseudomallei. Resistance to gentamicin is generally a hallmark of B. pseudomallei, and gentamicin is a selective agent in media used for diagnosis of melioidosis.
Currie, Bart J., Fam, TemLom, Giffard, Philip M., Hii, KingChing, Kaestli, Mirjam, Keim, Paul, Mayo, Mark, Mohan, Anand, Ngian, HieUng, Ooi, MongHow, Podin, Yuwana, Price, Erin P., Sarovich, Derek S., Tuanyok, Apichai, Wong, IngTien, Wong, Jack, Wong, JinShyan, Wong, See-Chang   +17 more
core   +1 more source

Bifidobacterium bifidum CCFM1163 Alleviates Cathartic Colon Through the Acetate/Propionate‐GPR41‐Gβγ Pathway

Food Frontiers, Volume 6, Issue 2, Page 852-871, March 2025.
Bifidobacterium bifidum CCFM1163 alleviates cathartic colon by regulating the gut microbiota, promoting the secretion of acetate and propionate, and activating the downstream GPR41‐Gβγ pathway, thus enhancing both the intestinal mechanical barrier and the enteric nervous system. ABSTRACT Cathartic colon, a form of slow‐transit constipation, arises from
Yin Huang, Nan Tang, Yifan Xue, Jiazhen Li, WenXu Liu, Shengnan Zhu, Linlin Wang, Gang Wang, Wei Chen, Jianxin Zhao   +9 more
wiley   +1 more source

Identification and characterisation of toxin-antitoxin systems (TA) in Burkholderia pseudomallei [PDF]

, 2013
The aim of this study was to identify and characterise type II toxin-antitoxin (TA) systems in Burkholderia pseudomallei, the causative agent of the human disease melioidosis. 8 putative TA systems were identified within the genome of B. pseudomallei
Butt, Aaron Trevor
core  

Sepsis: the evolution of molecular pathogenesis concepts and clinical management

MedComm, Volume 6, Issue 3, March 2025.
(A) The innate and adaptive immune responses established during long‐term evolution can eliminate most invading microorganisms. (B) Sepsis only occurs when the balance is disrupted and the pathogen force overwhelms the host's defense force. (C) Only when the superposition of external forces (sensitive antimicrobial drugs) and internal forces ...
Zhongxue Feng, Lijun Wang, Jing Yang, Tingting Li, Xuelian Liao, Yan Kang, Fei Xiao, Wei Zhang   +7 more
wiley   +1 more source

Melioidosis

Current Opinion in Infectious Diseases, 2006
Melioidosis is increasingly recognized around the world. Despite several decades of clinical research, the mortality rate for melioidosis remains high. This review focuses on studies that relate to patient management, including risk factors, diagnosis, treatment and prediction of the outcome.
openaire   +2 more sources

Molecular Investigations of PenA-mediated β-lactam Resistance in Burkholderia pseudomallei [PDF]

, 2011
Burkholderia pseudomallei is the etiological agent of melioidosis. Because of the bacterium’s intrinsic resistance and propensity to establish latent infections, melioidosis therapy is complicated and prolonged. Newer generation b-lactams, specifically
Drew A Rholl, Krisztina M Papp-Wallace, Andrew P Tomaras, Michael L Vasil, Robert A Bonomo, Robert A Bonomo, Herbert P Schweizer   +6 more
core   +1 more source

Burkholderia pseudomallei in Colombia: Laboratory Approaches to Enhance Diagnostic Accuracy

International Journal of Microbiology, Volume 2025, Issue 1, 2025.
Background Melioidosis is a challenging disease to diagnose, and diagnostic complications can delay treatment, adversely impacting patient outcomes. Methods Over a period of 1 year, 68 isolates, initially identified as Burkholderia spp. or oxidase‐positive nonfermenting Gram‐negative bacilli (excluding Pseudomonas aeruginosa), were collected from ...
Soraya Morales-Lopez, Yeneiris Villero Wolf, Deyner Lechuga, Luis Caicedo, Yiceth Acosta Triana, Liliana Gomez, Luis Rodrigo Ramirez, Leandro Narvaez, Heidy Pinzon, Kelin Esquea, Rafael Barros, Pedro Martinez Ramos, Adriana Marin, Claudia Marcela Parra, Esha Saini   +14 more
wiley   +1 more source