Results 71 to 80 of about 9,609 (223)

Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon

Advanced Therapeutics, Volume 8, Issue 4, April 2025.
Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap, Pankaj R. Khuspe, Sagar R. Pardeshi, Md Jasim Uddin, Ushasi Das, Navnath T. Hatvate, Satish Rojekar, Prabhanjan Giram, Mohammad Khalid, Yahya E. Choonara, Md. Faiyazuddin   +10 more
wiley   +1 more source

Prolonged Fever in Children: An Inpatient Diagnostic Framework for Infections in Australia

Journal of Paediatrics and Child Health, Volume 61, Issue 4, Page 532-539, April 2025.
ABSTRACT There are many causes of fever in children, ranging from common and self‐limiting to serious and life threatening. Careful assessment of children with prolonged fever without an obvious or identified source requires detailed history and examination with consideration of infections unique to the specific geographical region and individual ...
Heshani Rupasinghe, Clare Nourse, Jennifer Robson, Angela Berkhout   +3 more
wiley   +1 more source

EMERGENCY PROPHYLAXIS OF EXPERIMENTAL MELIOIDOSIS USING SYNTHETIC IMMUNOMODULATORS AND HETEROLOGOUS VACCINES

RUDN Journal of Medicine, 2018
Melioidosis is a particularly dangerous infection caused by Burkholderia pseudomallei , against which a vaccine has not yet been created. In this regard, the development of effective treatment regimens and emergency prevention of melioidosis is very ...
I A Khabarova, S I Zhukova, K A Rotov, E A Snatenkov, A V Toporkov, D V Viktorov   +5 more
doaj   +1 more source

Septicemic melioidosis complicating undiagnosed chronic kidney disease and beta-thalassemia minor in a Bangladeshi farmer

Saudi Journal of Kidney Diseases and Transplantation, 2020
Melioidosis is an emerging infectious disease in many countries including Bangladesh. Patients with diabetes mellitus are at increased risk for infection by Burkholderia pseudomallei, the causative agent for melioidosis.
Muhammad Abdur Rahim, Muhammad Abu Yousuf Khan, Tufayel Ahmed Chowdhury, Mehruba Alam Ananna   +3 more
doaj   +1 more source

Bifidobacterium bifidum CCFM1163 Alleviates Cathartic Colon Through the Acetate/Propionate‐GPR41‐Gβγ Pathway

Food Frontiers, Volume 6, Issue 2, Page 852-871, March 2025.
Bifidobacterium bifidum CCFM1163 alleviates cathartic colon by regulating the gut microbiota, promoting the secretion of acetate and propionate, and activating the downstream GPR41‐Gβγ pathway, thus enhancing both the intestinal mechanical barrier and the enteric nervous system. ABSTRACT Cathartic colon, a form of slow‐transit constipation, arises from
Yin Huang, Nan Tang, Yifan Xue, Jiazhen Li, WenXu Liu, Shengnan Zhu, Linlin Wang, Gang Wang, Wei Chen, Jianxin Zhao   +9 more
wiley   +1 more source

Melioidosis: Clinical impact and public health threat in the tropics.

PLoS Neglected Tropical Diseases, 2017
This review briefly summarizes the geographical distribution and clinical impact of melioidosis, especially in the tropics. Burkholderia pseudomallei (a gram-negative bacterium) is the major causative agent for melioidosis, which is prevalent in ...
Ramar Perumal Samy, Bradley G Stiles, Gautam Sethi, Lina H K Lim   +3 more
doaj   +1 more source

Sepsis: the evolution of molecular pathogenesis concepts and clinical management

MedComm, Volume 6, Issue 3, March 2025.
(A) The innate and adaptive immune responses established during long‐term evolution can eliminate most invading microorganisms. (B) Sepsis only occurs when the balance is disrupted and the pathogen force overwhelms the host's defense force. (C) Only when the superposition of external forces (sensitive antimicrobial drugs) and internal forces ...
Zhongxue Feng, Lijun Wang, Jing Yang, Tingting Li, Xuelian Liao, Yan Kang, Fei Xiao, Wei Zhang   +7 more
wiley   +1 more source

The characteristics and clinical course of patients with melioidosis and cancer.

PLoS Neglected Tropical Diseases
BackgroundPatients with an active cancer are more likely to develop melioidosis, but the characteristics and clinical course of melioidosis in patients with cancer have not been examined in detail.
Tej Shukla, Simon Smith, Kristoffer Johnstone, Patrick Donald, Josh Hanson   +4 more
doaj   +1 more source

Burkholderia pseudomallei in Colombia: Laboratory Approaches to Enhance Diagnostic Accuracy

International Journal of Microbiology, Volume 2025, Issue 1, 2025.
Background Melioidosis is a challenging disease to diagnose, and diagnostic complications can delay treatment, adversely impacting patient outcomes. Methods Over a period of 1 year, 68 isolates, initially identified as Burkholderia spp. or oxidase‐positive nonfermenting Gram‐negative bacilli (excluding Pseudomonas aeruginosa), were collected from ...
Soraya Morales-Lopez, Yeneiris Villero Wolf, Deyner Lechuga, Luis Caicedo, Yiceth Acosta Triana, Liliana Gomez, Luis Rodrigo Ramirez, Leandro Narvaez, Heidy Pinzon, Kelin Esquea, Rafael Barros, Pedro Martinez Ramos, Adriana Marin, Claudia Marcela Parra, Esha Saini   +14 more
wiley   +1 more source

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles.

, 2014
Burkholderia pseudomallei (Bp) is the causative agent of the infectious disease melioidosis. To investigate population diversity, recombination, and horizontal gene transfer in closely related Bp isolates, we performed whole-genome sequencing (WGS) on ...
Studholme, David J., Holden, Mathew TG, Ong, C, Beacham, I, Parkhill, J, Harting, J, Chen, Swaine L., Mehershahi, K, Holden, Matthew T. G., Nandi, T, T.G. Holden, Matthew, Didelot, X, Peak, I, Baybayan, Primo, Peak, Ian, Sim, B, Hoon, CH, Nandi, Tannistha, Boddey, J, Boddey, Justin, Boddey, Justin A., Holden, Matthew, J. Studholme, David, Baybayan, P, Michell, S, Essex-Lopresti, AE, Guo, Yan, Sim, Bernice, Didelot, Xavier, Titball, Richard W., Chen, SL, Smither, Sophie, Smiters, Sophie, Beacham, Ifor, Holden, Matthew TG, Smither, S, How, LC, Nelson, Michelle, Ong, Catherine, Tan, P, Wang, S, Aw, LT, Nelson, M, Mitchell, Stephen, Michell, Stephen, Aw, Lay Tin, E. Essex-Lopresti, Angela, Chen, Swaine, Chen, Swaine L, Titball, Richard, Mehrashahi, Kurosh, Hoon, Chua Hui, Boddey, Justin A, Sarkar-Tyson, M, Parkhill, Julian, Mehershahi, Kurosh, Guo, Y, Tan, Patrick, How, Lee Chee, W. Titball, Richard, Sarkar-Tyson, Mitali, Wang, Susana, Essex-Lopresti, Angela, Studholme, David J, Harting, John   +64 more
core   +1 more source