Results 51 to 60 of about 10,735 (222)

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
Camila S. de Freitas, Eduardo Oliveira S. da Silva, Daniela C. Tristão, Guilherme M. Antar, Daniela P. Lage, Dóris M. Abrão, Luciana M. Ribeiro Antinarelli, Elaine S. Coimbra, João Henrique G. Lago, Eduardo A. F. Coelho   +9 more
wiley   +1 more source

CD4+ T cell epitopes of FliC conserved between strains of Burkholderia: implications for vaccines against melioidosis and cepacia complex in cystic fibrosis.

, 2014
Burkholderia pseudomallei is the causative agent of melioidosis characterized by pneumonia and fatal septicemia and prevalent in Southeast Asia. Related Burkholderia species are strong risk factors of mortality in cystic fibrosis (CF).
Nithichanon, Arnone, Lertmemongkolchai, Ganjana, Chu, Karen KY, Khaenam, Prasong, Rinchai, Darawan, Maillere, Bernard, Robinson, John H, Favry, Emmanuel, Bancroft, Gregory J, Reynolds, Catherine J, Altmann, Daniel M, Spink, Natasha, Boyton, Rosemary J, Musson, Julie A, De Soyza, Anthony   +14 more
core   +1 more source

Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler, Ingrid Richter, Katharina Dornblut, Alicia Scharf, Christian Hertweck   +4 more
wiley   +2 more sources

Melioidosis [PDF]

Indian Journal of Medical Research, 2019
Annamalai, Anand K., Padmini, Kothandaramaraju   +1 more
  +8 more sources

The epidemiology and clinical features of melioidosis in the Lao PDR: a 21-year prospective hospital-based cohort study

BMC Infectious Diseases
Background Melioidosis, caused by Burkholderia pseudomallei, poses a significant health risk in tropical and subtropical regions. The disease is endemic in Southeast Asia, including the Lao PDR (Laos), where the first case was confirmed in 1999. Although
The Lao Melioidosis Research Group
doaj   +1 more source

Culture‐Negative Pyogenic Liver Abscess Presenting as Lung Abscess and Empyema Through Transdiaphragmatic Spread

Respirology Case Reports, Volume 14, Issue 8, August 2026.
Dyspnoea, cough and weight loss initially suggested thoracic malignancy. CT thorax–abdomen demonstrated a large right subcapsular pyogenic liver abscess with contiguous non‐fistulous transdiaphragmatic spread causing lung abscess and pleural empyema. Image‐guided liver abscess drainage and prolonged antimicrobial therapy led to sustained clinical and ...
Zhong Xhen Khor, Kai Sheng Chung, Jia Yi Lim, Christine Hwee Ming Tay, Atiqah Binti Ayub   +4 more
wiley   +1 more source

Melioidosis in the head-and-neck region

Journal of Clinical and Scientific Research
Burkholderia pseudomallei, an environmental saprophyte, causes an infection that results in melioidosis. A high case-fatality rate is linked to it. Melioidosis is becoming an increasingly global infection. It can present a wide spectrum of manifestations
Santosh Kumar Swain, Vasudha Singh
doaj   +1 more source

Melioidosis in the remote Katherine region of northern Australia.

PLoS Neglected Tropical Diseases, 2022
Melioidosis is endemic in the remote Katherine region of northern Australia. In a population with high rates of chronic disease, social inequities, and extreme remoteness, the impact of melioidosis is exacerbated by severe weather events and ...
Kay Hodgetts, Mariana Kleinecke, Celeste Woerle, Mirjam Kaestli, Richard Budd, Jessica R Webb, Linda Ward, Mark Mayo, Bart J Currie, Ella M Meumann   +9 more
doaj   +1 more source

Pulmonary Melioidosis

Chest, 1995
Melioidosis is the name given to all diseases caused by the bacterium Pseudomonas pseudomallei. Melioidosis is a tropical disease and prevails in parts of Southeast Asia, northern Australia, and Central and South America. However, in recent years, cases of melioidosis have been reported in the United States and other areas.
Osterberg, LG, Ip, M, Raffin, TA, Chau, PY   +3 more
openaire   +4 more sources

Korat‐Scrub Typhus Score: A Clinical Tool for Predicting Scrub Typhus in Patients With Acute Undifferentiated Febrile Illness

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1066-1072, August 2026.
ABSTRACT Objective Scrub typhus is a major cause of acute undifferentiated febrile illness (AUFI) in the Asia–Pacific region. Nonspecific presentation, limited diagnostic accuracy and delayed treatment increase morbidity and mortality. This study aimed to develop a simple clinical score for early diagnosis in adults with AUFI. Methods A cross‐sectional
Wilawan Thipmontree, Ekkarat Wongsawat, Saowaluk Silpasakorn, Yupin Suputtamongkol   +3 more
wiley   +1 more source