Results 121 to 130 of about 25,852 (227)

Isolated lung perfusion with melphalan for the treatment of metastatic pulmonary sarcoma

, 1996
Objective: Isolated lung perfusion allows the delivery of high-dose chemotherapy to the perfused lung and is an efficacious modality in the treatment of pulmonary metastases in the rat. Melphalan activity in this model was investigated. Methods: Toxicity
Abecasis, Nuno, Ross, Howard M., Sachar, Komal S., Nawata, Sumihiko, Burt, Michael E., Abolhoda, Amir, Cheng, Huiming   +6 more
core   +1 more source

Challenges in Implementing Revocation of Oncology Drugs Under Conditional Early Approval in Japan: Regulatory Insights From Comparisons With FDA/EMA

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Expedited pathways in the United States (U.S.), European Union (EU), and Japan (JP) enable earlier access to innovative therapies for rare and serious diseases. In 2025, Japan explicitly introduced revocation provisions to its Conditional Early Approval (CEA).
Takahiro Handa, Arata Tanaka, Mayumi Shikano, Rika Wakao   +3 more
wiley   +1 more source

Chemotherapy‐induced alopecia: an exploratory questionnaire‐based study from Israel comparing knowledge, attitudes, and management practices among dermatologists and oncologists

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 6, Page 778-787, June 2026.
Summary Background and Objectives: Chemotherapy‐induced alopecia, encompassing both acute reversible alopecia and its persistent form, significantly impacts patients' quality of life but remains inadequately addressed. This study aimed to compare dermatologists' and oncologists' knowledge, attitudes, and practices regarding chemotherapy‐induced ...
Anna Lyakhovitsky, Oz Segal, Ester Vizan, Arad Dotan, Riad Kassem, Keren Lyakhovitsky, Avner Shemer, Baruch Kaplan, Eran Galili, Aviv Barzilai   +9 more
wiley   +1 more source

Chemotherapie‐induzierte Alopezie: eine explorative Fragebogenstudie aus Israel zum Vergleich der Kenntnisse, Einstellungen und Managementpraktiken bei Dermatologen und Onkologen

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 6, Page 778-788, June 2026.
Zusammenfassung Hintergrund und Ziele Chemotherapieinduzierte Alopezie (CIA), sowohl die akute reversible als auch die persistente Form, hat erhebliche Auswirkungen auf die Lebensqualität der Patienten, wird aber immer noch unzureichend behandelt. Diese Studie hatte das Ziel, die Kenntnisse, Einstellungen und Praktiken von Dermatologen und Onkologen im
Anna Lyakhovitsky, Oz Segal, Ester Vizan, Arad Dotan, Riad Kassem, Keren Lyakhovitsky, Avner Shemer, Baruch Kaplan, Eran Galili, Aviv Barzilai   +9 more
wiley   +1 more source

Prophylactic Donor Lymphocyte Infusions in Pediatric Patients With High‐Risk Hematological Malignancies

European Journal of Haematology, Volume 116, Issue 6, Page 907-914, June 2026.
ABSTRACT Introduction Allogeneic stem cell transplantation (allo‐SCT) and donor lymphocyte infusions (DLI) can elicit a graft‐versus‐leukemia (GvL) effect in pediatric patients with hematological malignancies. We report our single‐center experience with prophylactic DLI in high‐risk pediatric patients with leukemia or lymphoma, focusing on feasibility,
Denise Epple, Katja Gall, Luisa Paschke, Hans‐Jochem Kolb, Angela Wawer, Hans Knabe, Irene von Luettichau, Julia Hauer, Uwe Thiel   +8 more
wiley   +1 more source

Correlation between Melphalan chemotherapy with longitudinal global strain indices of the left ventricle in multiple myeloma patients: a velocity vector imaging (VVI) echocardiography study [PDF]

Caspian Journal of Internal Medicine
Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cells, leading to the production of monoclonal immunoglobulins. High-dose chemotherapy with autologous stem cell transplant has been used in the treatment of patients with ...
Liaosadat Mirsafaee, Mohammad Dehghani Firouzabadi, Sayeh Parkhideh, Hassan Vahidnezhad, Fatemeh Dehghani Firouzabadi, Maryam Arab, David M. Yousem, Mersedeh Karvandi   +7 more
doaj  

Autologous stem cell transplantation in multiple myeloma at Chris Hani Baragwanath Academic Hospital

South African Journal of Oncology
Background: Autologous stem cell transplantation (ASCT) is the standard of care for multiple myeloma (MM), even in the era of novel therapeutic agents. Data regarding ASCT outcomes in MM is lacking in South Africa.
Vedanand Rawoo, Moosa Patel, Atul B. Lakha, Vinitha Philip, Muhammed F. Waja   +4 more
doaj   +1 more source

Insulin Signalling‐Inducible IFITM1 Promotes Multiple Myeloma Progression and Bortezomib Resistance

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Insulin substantially promotes the growth of malignant cells that overexpress the insulin receptor (INSR), and insulin excess has been recognised as a cancer‐promoting factor in patients. Interferon‐induced transmembrane protein 1 (IFITM1) is also overexpressed in various cancers.
Ji‐Young Lim, Yeojin Kim, Sung‐Soo Park, Jungyeon Lee, Chang‐Ki Min   +4 more
wiley   +1 more source

Mediastinal Lymphoma in 70 Dogs Treated With Lomustine or Anthracycline‐Based Multi‐Agent Chemotherapy

Veterinary and Comparative Oncology, Volume 24, Issue 2, Page 382-392, June 2026.
ABSTRACT Primary mediastinal lymphoma is rare in dogs and literature exploring this disease is limited. Therefore, the aim of this study was to describe presentation, treatment and outcome in a large cohort of dogs with mediastinal lymphoma and explore prognostic factors including chemotherapy protocol. This retrospective multi‐institute study included
Diogo Machado, Jose Alvarez Picornell, Isabel Amores‐Fuster, Sarah Benjamin, Thomas Kearns, Alenka Lavra Zajc, Yike Bing, Katie A. McNaught, Maria Sava, Charlotte Johnston, Beth Rolf, Andrew D. Yale   +11 more
wiley   +1 more source

ERG and OCT abnormalities in retinoblastoma after melphalan intravitreous injection

The authors report full-field electroretinogram and optical coherence tomography findings of intravitreal melphalan retinal toxicity. An 18-month-old girl with unilateral group D retinoblastoma was evaluated with light-adapted 3 full-field ...
Moreto, Renata, Bergamo, Maristella, Jorge, Rodrigo, Albuquerque, Marina L. de, Corrêa, Zélia M.   +4 more
core   +1 more source