Results 51 to 60 of about 25,852 (227)

Impact of melphalan day -1 vs day -2 on outcomes after autologous stem cell transplant for multiple myeloma

open access: yesFrontiers in Immunology
BackgroundMelphalan is the most common conditioning regimen used prior to autologous stem cell transplant (ASCT); however, there are varying data on optimal melphalan timing prior to transplant for best safety and efficacy.
Aimee Merino   +11 more
doaj   +1 more source

Current Trends in the Management of Retinoblastoma

open access: yesTürk Oftalmoloji Dergisi, 2014
Retinoblastoma is the most common primary intraocular malignant tumor of early childhood, and 95% of all cases are diagnosed before the age of 5 years.
Hayyam Kıratlı, Berçin Tarlan
doaj   +1 more source

A complex case of necrobiotic xanthogranuloma with IgG‐kappa paraproteinemia: Disease regression achieved with melphalan and prednisone combination therapy

open access: yesClinical Case Reports, 2022
Necrobiotic xanthogranuloma (NXG) is a rare dermatosis that is often associated with monoclonal paraproteinemia and hematological malignancies. We report the rare case of an 84‐year‐old gentleman with extensive truncal NXG and IgG‐kappa paraproteinemia ...
Jacques A. J. Malherbe, Julian Cooney
doaj   +1 more source

Intravitreal chemotherapy in the management of retinoblastoma in a resource-limited setting

open access: yesAfrican Vision and Eye Health, 2022
Intravitreal chemotherapy (IVitC) in the management of retinoblastoma has increased the rate of globe salvage, specifically in patients with recurrent disease and associated vitreous seeds.
Kashmira Rawjee   +2 more
doaj   +1 more source

Pseudohyperphosphatemia in Multiple Myeloma: A Systematic Review of Case Reports and Case Series

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Pseudohyperphosphatemia (PHP) is a clinically significant laboratory artifact in patients with multiple myeloma (MM). It is often caused by paraprotein interference with phosphate assays. This systematic review summarizes reported cases, underlying mechanisms, and diagnostic approaches to distinguish spurious from true hyperphosphatemia.
Mahsa Dabir   +3 more
wiley   +1 more source

Amifostine (WR-2721) selective protection against melphalan genotoxicity [PDF]

open access: yes, 2000
Amifostine (WR-2721) is an aminothiol compound dephosphorylated at the tissue site by alkaline phosphatase to the active metabolite, which is able to inactivate electrophilic substances and scavenge free radicals.
E. Anceschi   +11 more
core   +1 more source

ERG and OCT abnormalities in retinoblastoma after melphalan intravitreous injection

open access: yes, 2022
The authors report full-field electroretinogram and optical coherence tomography findings of intravitreal melphalan retinal toxicity. An 18-month-old girl with unilateral group D retinoblastoma was evaluated with light-adapted 3 full-field ...
Marina L. de Albuquerque (12684554)   +4 more
core   +1 more source

Successfully performed video capsule endoscopy in an 8‐month‐old infant weighing 7.5 kg

open access: yesJPGN Reports, EarlyView.
Abstract Video capsule endoscopy (VCE) is a well‐established diagnostic tool for examining the small bowel. Limited data exist on its use in infants. To our knowledge, we present the first detailed case of a successful PillCam®SB3‐VCE performed in an 8‐month‐old infant weighing 7.5 kg with suspected small bowel bleeding following allogeneic ...
Paul‐Christoph Zeisler   +3 more
wiley   +1 more source

Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines

open access: yes, 2009
There is a considerable variation in efficacy of melphalan therapy in multiple myeloma (MM) and other hematopoietic tumors. We hypothesized that this may be due to variations in the expression of influx and efflux transporters of melphalan.
Tzvetkov, Mladen Vassilev   +7 more
core   +1 more source

Assessment of Treatment Response in Patients With Scleromyxedema by the Double Modified Rodnan Skin Score

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Scleromyxedema (SMX) is a cutaneous mucinosis characterised by an abnormal accumulation of mucin in the skin and limited treatment options. Assessment of therapy response during treatment is challenging. Objectives Patients with SMX receiving high‐dose intravenous IVIg therapy were included to assess validity of the double modified ...
Julia K. Winkler, Alexander H. Enk
wiley   +1 more source

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