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European Journal of Pharmaceutics and Biopharmaceutics, 2016
The pharmaceutical industry has a growing interest in alternative manufacturing models allowing automation and continuous production in order to improve process efficiency and reduce costs. Implementing a switch from batch to continuous processing requires fundamental process understanding and the implementation of quality-by-design (QbD) principles ...
Tinne, Monteyne +4 more
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The pharmaceutical industry has a growing interest in alternative manufacturing models allowing automation and continuous production in order to improve process efficiency and reduce costs. Implementing a switch from batch to continuous processing requires fundamental process understanding and the implementation of quality-by-design (QbD) principles ...
Tinne, Monteyne +4 more
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Preparing of aspirin sustained-release granules by hot-melt granulation and micro-crystal coating
Drug Development and Industrial Pharmacy, 2019In this work, aspirin (ASP) sustained granules were prepared using micro-crystal coating and hot-melt granulation, respectively. In the process of micro-crystal coating, PVP was used to form the isolation layer and then coated with either Eudragit RS/RL30D or ethyl cellulose (EC) as sustained-release layers to prepare sustained granules (the granules ...
Ran, Li +5 more
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Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior
International Journal of PharmaceuticsTwin-screw melt granulation (TSMG) relies on the dispersive and distributive mixing at the kneading zone for granule growth to happen highlighting the critical role played by the kneading elements in TSMG. Despite extensive research conducted on the impact of screw geometry in melt compounding, there is not enough literature for TSMG.
Adwait Pradhan +7 more
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Study of Melting Ability of Granulated Glass Batch
Key Engineering Materials, 2016In the conventional soda-lime glass production, loose raw materials are normally mixed into a glass batch for melting. Dusting and segregation of the loose glass batch are always occurred during the melting process inside the glass furnace. Also, the loose glass batch has low thermal conductivity which limits the glass melting ability and pulling rate ...
Kanit Tapasa +3 more
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Particulate Science and Technology, 2015
The purpose of this research was to develop and optimize a sustained-release multiple unit floating system of a highly water-soluble drug, Acyclovir, using Gelucire 43/01 as lipid carrier and ethyl cellulose (EC) and methyl cellulose (MC) as release rate modifiers.
Ravindra S. Thakare, Sanjay B. Patil
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The purpose of this research was to develop and optimize a sustained-release multiple unit floating system of a highly water-soluble drug, Acyclovir, using Gelucire 43/01 as lipid carrier and ethyl cellulose (EC) and methyl cellulose (MC) as release rate modifiers.
Ravindra S. Thakare, Sanjay B. Patil
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Unraveling local heat generation in twin-screw melt granulation
International Journal of PharmaceuticsGranule growth in twin-screw melt granulation (TSMG) is driven by viscous and frictional heat dissipation at the kneading block. The formation of larger, stronger granules requires the screws to input more energy into processing the material, resulting in local heat generation (ΔTlocal), as indicated by difference between the peak granule temperature ...
Niyati Niranjan, Kodange +6 more
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A REVIEW ON MELT GRANULATION TECHNIQUES
In the process of creating pharmaceutical oral dosage forms, granulation is one of the most crucial unit processes. Granulation will enhance flow and compression properties, lessen segregation, increase content uniformity, and get rid of too many tiny particles.openaire +1 more source
Vibratory granulation op a melt
Soviet Powder Metallurgy and Metal Ceramics, 1989A. V. Stepanenko +3 more
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