Results 31 to 40 of about 1,899 (207)

Impact of the manufacturing technique on the dissolution-enhancement functionality of PEG4000 in Cilostazol tablets [PDF]

Pharmacia, 2021
Cilostazol was selected as poorly-soluble model drug to investigate the impact of the manufacturing method on the excipient functionality of PEG4000 at various levels.
Obada Sawafta, Sonia Alhadid, Izz Aldeen Abu Awwad, Eman Migdadi, Ahmad Aljaberi   +4 more
doaj   +3 more sources

Preparation and characterisation of ibuprofen–poloxamer 188 granules obtained by melt granulation

European Journal of Pharmaceutical Sciences, 2002
The aim of this study was to prepare, by melt granulation, granules containing ibuprofen as a poorly water soluble model drug in order to improve its dissolution rate and its availability; lactose as a diluent and poloxamer 188 (Lutrol F68), as a new meltable hydrophilic binder, were used.
Nadia, Passerini, Beatrice, Albertini, Marisa L, González-Rodríguez, Cristina, Cavallari, Lorenzo, Rodriguez   +4 more
openaire   +2 more sources

Evaluation of gum mastic (Pistacia lentiscus) as a microencapsulating and matrix forming material for sustained drug release

Asian Journal of Pharmaceutical Sciences, 2017
In this study, a natural gum mastic was evaluated as a microencapsulating and matrix-forming material for sustained drug release. Mastic was characterized for its physicochemical properties.
Dinesh M. Morkhade
doaj   +1 more source

Downstream processing from melt granulation towards tablets: In-depth analysis of a continuous twin-screw melt granulation process using polymeric binders [PDF]

European Journal of Pharmaceutics and Biopharmaceutics, 2018
The concept of twin-screw melt granulation (TSMG) has steadily (re)-gained interest in pharmaceutical formulation development as an intermediate step during tablet manufacturing. However, to be considered as a viable processing option for solid oral dosage forms there is a need to understand all critical sources of variability which could affect this ...
Grymonpré, Wouter, Verstraete, Glenn, Vanhoorne, Valérie, Remon, Jean Paul, De Beer, Thomas, Vervaet, Chris   +5 more
openaire   +3 more sources

Characterization and Prediction of the Non-Bonded Molecular Interactions between Racemic Ibuprofen and α-Lactose Monohydrate Crystals Produced from Melt Granulation and Slow Evaporation Crystallization

Indonesian Journal of Chemistry, 2020
Granulation of racemic ibuprofen (±IBP) and α-lactose monohydrate (ALM) at a slightly lower (±IBP) melting point is an efficient method of binding the active pharmaceutical ingredients (API) and excipient in a binderless condition.
Zulfahmi Lukman, Nornizar Anuar, Noor Fitrah Abu Bakar, Norazah Abdul Rahman   +3 more
doaj   +1 more source

Development of gastroretentive floating granules with gentian root extract by hot-melt granulation [PDF]

Lekovite sirovine, 2020
<p>The roots of yellow gentian, <i>Gentiana lutea</i> L. (<i>Gentianaceae</i>) are used in traditional medicine for the treatment of gastrointestinal disorders, with the literature data indicate a local gastric effect of gentian root extract (GRE) and support the use
Jelena Mudrić, Mirjana Pajić, Dubravka Bigović, Jelena Đuriš   +3 more
openaire   +1 more source

Unidirectional Tape‐Based Composites from Hemp and Pineapple Leaf Fiber: Mechanical Performance in Conventional and Bio‐Based Matrices

Advanced Engineering Materials, EarlyView.
The study investigates novel semi‐finished products made of unidirectionally arranged hemp or pineapple leaf fiber‐reinforced composites produced from different matrices. The materials are analyzed in terms of their mechanical and interfacial properties and void content.
Nina Graupner, Raja Bade, Valentin Ackermann, Roja M. Baumann, Corvin Bischoff, Jona F. Ebeling, Oskar Glenz, Marlo Groh, Jonathan Groth, Finja Hiller, Tom Hirschmüller, Felix Menke, Syntcha Ngantchou Lecdou, Mika Ohler, Daniel Rafii Vardiny, Darius Richter, Dario Röper, Henrik Schumacher, Theresa Stein, Benjamin Vorbeck, Elisabeth Wermter, Kay Kölzig, Jörg Müssig   +22 more
wiley   +1 more source

Four‐Point Bending Tests at High Temperatures on Commercial MgO‐C Refractory Bricks with and Without Recyclate Considering Different Carbon Contents

Advanced Engineering Materials, EarlyView.
Four‐point bending tests are conducted in an argon atmosphere on commercial MgO‐C brick grades with and without MgO‐C recyclate from room temperature up to 1300 °C. No detrimental effect of the MgO‐C recyclates on bending strength is found. Instead, a decisive influence of the total carbon content is observed, with lower total carbon contents ...
Alexander Schramm, Lukas Knöchel, Thomas Schemmel, Christos G. Aneziris, Anja Weidner, Horst Biermann   +5 more
wiley   +1 more source

Comprehensive review on modern techniques of granulation in pharmaceutical solid dosage forms

Intelligent Pharmacy
This comprehensive review explores modern granulation techniques in pharmaceutical dosage forms along with conventional methods, focusing on dry granulation and wet granulation.
Anil Kumar Vadaga, Sai Shashank Gudla, Gnanendra Sai Kumar Nareboina, Hymavathi Gubbala, Bhuvaneswari Golla   +4 more
doaj   +1 more source

Application of multivariate techniques in the evaluation of melt granulation products

Brazilian Journal of Pharmaceutical Sciences, 2011
In this work, principal component analysis and cluster analysis were applied as helping tools to extract useful information in the development of formulations and manufacturing processes of melt granulates.
Ana Teresa Ochoa Andrade
doaj   +1 more source