Macromol, 2021 High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely known, extended-release polymers. Conventional high-molecular-weight HPMCs are preferred in extended-release applications but not widely used in twin-screw melt ...
Amol Batra +9 more
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Melt granulation as an alternative technique in solid dosage forms manufacture [PDF]
Arhiv za farmaciju, 2015 Conventional granulation methods are associated with significant disadvantages which have led to increased interest and investment in the development of alternative techniques.
Aleksić Ivana +4 more
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Effect of Mixing Elements on Granule Formation in Hot Melt Twin Screw Granulation [PDF]
Chemical Engineering Transactions, 2021 Twin screw granulation (TSG) has been applied to wet granulation, although its application in melt granulation has been more limited. This work explores potential advantages of hot melt granulation using twin screw extrusion.
Nana Sekyi +2 more
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Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends [PDF]
PharmaceuticsBackground/Objectives: This study evaluates the efficacy of twin screw melt granulation (TSMG), and hot-melt extrusion (HME) techniques in enhancing the solubility and dissolution of simvastatin (SIM), a poorly water-soluble drug with low bioavailability.
Rasha M. Elkanayati +6 more
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The Effect of Formulation Variables on the Manufacturability of Clopidogrel Tablets via Fluidized Hot-Melt Granulation—From the Lab Scale to the Pilot Scale [PDF]
PharmaceuticsSolid pharmaceutical formulations with class II active pharmaceutical ingredients (APIs) face dissolution challenges due to limited solubility, affecting in vivo behavior.
Béla Kovács +7 more
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Enhanced Dissolution and Oral Bioavailability of Tegoprazan Using D-α-Tocopheryl Polyethylene Glycol 1000 Succinate-Based Melt Granulation System [PDF]
MoleculesTegoprazan (TPZ) is a promising potassium-competitive acid blocker, but its pH-dependent low solubility often leads to erratic oral absorption. Although several hydrophilic polymer-based amorphous solid dispersions have been attempted to enhance ...
Min Gyeong Jeong +6 more
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Formulation and evaluation of bilayer tablet by using melt granulation technique for treatment of diabetes mellitus [PDF]
Journal of Pharmacy and Bioallied Sciences, 2012 The objective of present study was to prepare and characterize Bilayer tablet formulation containing Metformin HCl in extended release matrix form and Pioglitazone HCl in immediate release form for the treatment of diabetes mellitus.
Dhruvita Patel +2 more
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Comprehensive review on modern techniques of granulation in pharmaceutical solid dosage forms
Intelligent PharmacyThis comprehensive review explores modern granulation techniques in pharmaceutical dosage forms along with conventional methods, focusing on dry granulation and wet granulation.
Anil Kumar Vadaga +4 more
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British Journal of Pharmacy, 2022 The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size flexibility, the relative ...
Valentyn Mohylyuk +4 more
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The Impacts of Method Selectivity and Binders on the Properties of Carbamazepine Granules and Their Applications: A Case Study [PDF]
Pharmaceutical Sciences, 2022 Background: Carbamazepine (CBZ) is a BCS II class drug, having many challenges in solubility, flowability, and compactibility. The study focused on the improvement of solubility, flow behavior, and drug release of carbamazepine.
Rahul Tatyarao Shete +2 more
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