Twin-Screw Melt Granulation for Oral Solid Pharmaceutical Products [PDF]
Pharmaceutics, 2021 This article highlights the advantages of pharmaceutical continuous melt granulation by twin-screw extrusion. The different melt granulation process options and excipients are described and compared, and a case is made for expanded use of twin-screw melt
Seth P Förster, Erin Dippold
exaly +5 more sources
Effervescent Tablet Preparation by Twin-Screw Melt Granulation With Sorbitol as a Melt Binder [PDF]
PharmaceuticsMethods: Effervescent granules containing citric acid and sodium bicarbonate were successfully prepared for the first time via TS-MG using a polyol (sorbitol) as a melt binder.
Liga Lauberte +2 more
exaly +5 more sources
Material Transport Characteristics in Planetary Roller Melt Granulation [PDF]
Pharmaceutics, 2023 Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current
Tom Lang +3 more
doaj +5 more sources
Continuous Melt Granulation for Taste-Masking of Ibuprofen [PDF]
Pharmaceutics, 2021 Taste-masking of drugs, particularly to produce formulations for pediatric patients, can be challenging and require complex manufacturing approaches. The objective of this study was to produce taste-masked ibuprofen granules using a novel process, twin ...
Seth P. Forster, David B. Lebo
doaj +2 more sources
Soft-chewable paracetamol tablets by melt granulation method: Formulation and characterization [PDF]
Journal of Pharmacy and Bioallied Sciences, 2021 Background: Oral drug delivery is the most preferred route for drug administration in the world, with tablets being one of the most common dosage forms.
Awis Sukarni Mohmad Sabere +5 more
doaj +2 more sources
Improving Tableting Performance of Lactose Monohydrate by Fluid-Bed Melt Granulation Co-Processing [PDF]
Pharmaceutics, 2021 Co-processing is commonly used approach to improve functional characteristics of pharmaceutical excipients to become suitable for tablet production by direct compression.
Djordje Medarević +3 more
doaj +2 more sources
Twin Screw Melt Granulation: A Single Step Approach for Developing Self-Emulsifying Drug Delivery System for Lipophilic Drugs [PDF]
Pharmaceutics, 2023 The current research aims to improve the solubility of the poorly soluble drug, i.e., ibuprofen, by developing self-emulsifying drug delivery systems (SEDDS) utilizing a twin screw melt granulation (TSMG) approach.
Dinesh Nyavanandi +6 more
doaj +2 more sources
Rice Bran Wax-Based Matrix Tablets for Sustained Release of Diclofenac Sodium: Effects of Processing and Sintering [PDF]
PharmaceuticsBackground/Objectives: Rice bran wax (RBW), a natural hydrophobic byproduct of rice bran oil refining, was evaluated as a lipid matrix former for the sustained oral delivery of diclofenac sodium (DFS). Methods: Matrix tablets containing 100 mg DFS and 45–
Nisit Kittipongpatana +3 more
doaj +2 more sources
Tenofovir Hot-Melt Granulation using Gelucire® to Develop Sustained-Release Vaginal Systems for Weekly Protection against Sexual Transmission of HIV [PDF]
Pharmaceutics, 2019 Hot-melt granulation is a technique used to obtain granules by dispersing a drug in polymers at a high temperature. Tenofovir, an antiretroviral drug with proven activity as a vaginal microbicide, was dispersed in melted Gelucire® (or a mixture of ...
Fernando Notario-Pérez +5 more
doaj +2 more sources
Continuous melt granulation to develop high drug loaded sustained release tablet of Metformin HCl [PDF]
Asian Journal of Pharmaceutical Sciences, 2017 The present work explores the application of melt granulation technology to develop a high drug loaded sustained release matrix tablet of Metformin HCl using hydroxypropylcellulose (HPC) as a hydrophilic binder and stearic acid as an extrusion aid for ...
Pradnya Vaingankar, Purnima Amin
doaj +2 more sources