Results 71 to 80 of about 266,485 (298)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Laser Ablation-Inductively Coupled Plasma-Mass Spectrometric Analysis Methods of Melt Inclusions and Its Geological Applications

Yankuang ceshi, 2013
Melt inclusions in phenocrysts play a very important role in petrological research for reserving the only direct information available on the temperature, pressure and chemical compositions of the magmatic system at the time that the host minerals ...
ZHAO Ling-hao, ZHAN Xiu-chun, HU Ming-yue, FAN Chen-zi, SUN Dong-yang, LIU Chuan-bao   +5 more
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Hydrogen Isotope Composition of a Large Silicic Magma Reservoir Preserved in Quartz‐Hosted Glass Inclusions of the Bishop Tuff Plinian Eruption

Geochemistry, Geophysics, Geosystems, 2020
Water controls magmatic crystallization and drives volcanic eruptions, but little is known about its primary source in silicic systems. The hydrogen isotope composition of volcanic products provides a metric that can track and identify magmatic source ...
Kenneth S. Befus, Kristina J. Walowski, Richard L. Hervig, Jeffrey T. Cullen   +3 more
doaj   +1 more source

A three-dimensional study of a crustal low velocity region beneath the 9°03′N overlapping spreading center [PDF]

, 2003
Overlapping spreading centers (OSCs) play a key role in models of magma distribution at fast spreading ridges. To investigate the relationship between ridge-axis discontinuities and magma supply, we conducted a three-dimensional seismic reflection and ...
Harding, A.J., Pye, J, Kent, GM, Tong, CH, Tong, C.H., Sinha, MC, White, R.S., van Avendonk, H.J.A., Hobbs, R.W., Pye, J.W., Bazin, S, Harding, AJ, Barton, PJ, Hobbs, RW, Kent, G.M., Barton, P.J., Sinha, M.C., HJA, VA, Bazin, S., Orcutt, J.A., Singh, SC, Orcutt, JA, White, RS, Singh, S.C.   +23 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Do melt inclusions record the pre-eruptive volatile content of magmas?

, 2010
La pubblicazione discute della bontà dello studio delle inclusioni silicatiche (melt inclusions) quale strumento per registrare il contenuto in elementi volatili prima dell'evento ...
ESPOSITO R., DE VIVO, BENEDETTO, HUNTER J., BODNAR R. J.   +3 more
core  

MEETING REPORT: FIRST ITALIAN WORKSHOP ON FLUID AND MELT INCLUSIONS (Primo Workshop Nazionale sulle Inclusioni fluide e vetrose, WNI 2023)

The “First Italian Workshop on Fluid and Melt Inclusions” took place in the beautiful location of the Botanical Garden of Palermo, Sicily, Italy, on May 10–11, 2023. The workshop was organized by Dr. Francesco Maria Lo Forte and Prof.
Aiuppa A., Lo Forte F. M., Costa S.
core   +1 more source

Channelized melt flow in downwelling mantle: Implications for 226Ra-210Pb disequilibria in arc magmas [PDF]

, 2008
We present the results of an analytical model of porous flow of viscous melt into a steadily dilating ‘‘channel’’ (defined as a cluster of smaller veins) in downwelling subarc mantle.
Koenders, M. A., Petford, Nick; id_orcid, Koenders, M.A., Petford, N., Turner, S, Petford, Nick, Turner, S., Koenders, M A   +7 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source