Results 51 to 60 of about 279,876 (309)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Geochemistry, Geophysics, Geosystems, 2021 Quartz‐hosted melt inclusions are windows into the assembly and storage of compositionally zoned magmas systems like the giant magma body responsible for the 2,800 km3 Youngest Toba Tuff (YTT), Indonesia.
C. R. Tierney, M. R. Reid
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The Metallurgical Mechanisms of Inclusions in the FGH4096 Alloy during Electron Beam Refining [PDF]
TeshugangThe effect of different electron beam refining parameters on the type， quantity and size distribution of inclusions during melt solidification was studied. The content of O and N in FGH4096 alloy and the type， quantity and size distribution of inclusions
Dong Liyang, You Xiaogang, Dong Gengyi, Wang Yinong, Tan Yi
doaj +3 more sources
Survival times of anomalous melt inclusions from element diffusion in olivine and chromite
, 2007 The chemical composition of basaltic magma erupted at the Earth’s surface is the end product of a complex series of processes, beginning with partial melting and melt extraction from a mantle source and ending with fractional crystallization and crustal
Kamenetsky, V. S. +8 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
3D Diffusion of Water in Melt Inclusion‐Bearing Olivine Phenocrysts
Geochemistry, Geophysics, GeosystemsOlivine‐hosted melt inclusions are an important archive of pre‐eruptive processes such as magma storage, mixing and subsequent ascent through the crust.
Euan J. F. Mutch +2 more
doaj +1 more source
(Table 3) Composition of melt inclusions of samples from Zhupanovsky volcano
, 2011 (Table 3) Composition of melt inclusions of samples from Zhupanovsky ...
Maxim V Portnyagin (6960065) +5 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
(Table 2) Composition of matrix shards and melt inclusions in fallout tephra from ODP 125-782A
, 2003 (Table 2) Composition of matrix shards and melt inclusions in fallout tephra from ODP 125 ...
Susanne M Straub (6963908) +3 more
core +1 more source