Results 61 to 70 of about 279,876 (309)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

(Table 4) Magnesium numbers in melt inclusions in plagiopclase from ODP Holes 137-504B and 140-504B diabase

, 1995
(Table 4) Magnesium numbers in melt inclusions in plagiopclase from ODP Holes 137-504B and 140-504B ...
Naslund, Howard Richard, Johnson, Kevin T M, Kevin T M Johnson (6973082), Fisk, Martin R, Martin R Fisk (6959828), Howard Richard Naslund (6970757)   +5 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

(Table 3) Trace element analyses of silicate melt inclusions in plagioclase from ODP Holes 137-504B and 140-504B diabase

, 1995
(Table 3) Trace element analyses of silicate melt inclusions in plagioclase from ODP Holes 137-504B and 140-504B ...
Naslund, Howard Richard, Johnson, Kevin T M, Kevin T M Johnson (6973082), Fisk, Martin R, Martin R Fisk (6959828), Howard Richard Naslund (6970757)   +5 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

(Table 2) Major element analyses of silicate melt inclusions in plagioclase from ODP Holes 137-504B and 140-504B diabase

, 1995
(Table 2) Major element analyses of silicate melt inclusions in plagioclase from ODP Holes 137-504B and 140-504B ...
Naslund, Howard Richard, Johnson, Kevin T M, Kevin T M Johnson (6973082), Fisk, Martin R, Martin R Fisk (6959828), Howard Richard Naslund (6970757)   +5 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

(Tabel S5f) Olivine-hosted melt inclusions (uncorrected composition)

, 2018
(Tabel S5f) Olivine-hosted melt inclusions (uncorrected ...
Melanie Siegburg (6968786), Bach, Wolfgang, Rocholl, Alexander, Wolfgang Bach (6960488), Klügel, Andreas, Alexander Rocholl (5480873), Siegburg, Melanie, Andreas Klügel (6968789)   +7 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Geochemical signatures and melt inclusion evidence in peridotite xenoliths of Sinsanri, South Korea

Open Geosciences
Jeju Island, located in South Korea, is a Cenozoic intraplate volcanic feature in the East Asian region. The Sinsanri area on Jeju Island is well-known for its rich presence of xenoliths, making it a key site for finding these geological features ...
Khant Naing Aung, Lim Chungwan, Ryu Han-Sun, Moon Jinah, Kim Heejung   +4 more
doaj   +1 more source