Results 61 to 70 of about 266,485 (298)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

(Table 2) Chemical composition of homogenized melt inclusions in clinopyroxenes from rocks of the Malaita Island

, 2005
(Table 2) Chemical composition of homogenized melt inclusions in clinopyroxenes from rocks of the Malaita ...
Vladimir A Simonov (6960893), YuR Vasil'ev (6960899), Kovyazin, S V, S V Kovyazin (6960896), John J Mahoney (6960902), Vasil'ev, YuR, Simonov, Vladimir A, Mahoney, John J   +7 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Geochemical signatures and melt inclusion evidence in peridotite xenoliths of Sinsanri, South Korea

Open Geosciences
Jeju Island, located in South Korea, is a Cenozoic intraplate volcanic feature in the East Asian region. The Sinsanri area on Jeju Island is well-known for its rich presence of xenoliths, making it a key site for finding these geological features ...
Khant Naing Aung, Lim Chungwan, Ryu Han-Sun, Moon Jinah, Kim Heejung   +4 more
doaj   +1 more source

Improving magmatic CO2 reconstruction using X-ray Computed Tomography to accurately quantify melt inclusion volumes and geometries

Volcanica
Melt inclusions provide a critical archive of primary magmatic compositions, particularly for reconstructing volatile systematics that are otherwise obscured by syn-eruptive degassing.
Helen Thornhill, David Ferguson, Alice Macente, Felix Boschetty, Eduardo Morgado, Jason Harvey   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Halogen-bearing metasomatizing melt preserved in high-pressure (HP) eclogites of Pfaffenberg, Bohemian Massif [PDF]

European Journal of Mineralogy
Primary granitic melt inclusions are trapped in garnets of eclogites in the garnet peridotite body of Pfaffenberg, Granulitgebirge (Bohemian Massif, Germany).
A. Borghini, A. Borghini, S. Ferrero, S. Ferrero, P. J. O'Brien, B. Wunder, P. Tollan, J. Majka, J. Majka, R. Fuchs, K. Gresky   +10 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Variability of Mauna Loa melt inclusions

Nature Precedings, 2011
AbstractA major element of variability of olivine melt inclusions in Mauna Loa lavas is here proved to be strictly related to olivine crystallization at inclusion walls, at low pressure and decreasing temperature.In so doing it is probably worth it to interpret trace elements and isotope variability in these olivine trapped liquids as the effect of ...
Pietro Armienti, Daniela Gasperini
openaire   +2 more sources