Results 51 to 60 of about 94,908 (322)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Transglutaminase Crosslinked Milk Protein Concentrate and Micellar Casein Concentrate: Impact on the Functionality of Imitation Mozzarella Cheese Manufactured on a Small Scale Using a Rapid Visco Analyzer. [PDF]

Foods
In dairy-based imitation mozzarella cheese (IMC) formulations, intact casein is critical and imparts IMC with a firm and elastic, stringy, melted texture. Rennet casein (RCN) is the desired ingredient to provide intact casein in IMC and is preferred over
Salunke P, Metzger LE.
europepmc   +3 more sources

Application of Tumbling Melt Granulation Method to Prepare Controlled-Release Beads by Coating with Mixture of Functional Non-meltable and Meltable Materials.

Chemical and Pharmaceutical Bulletin, 1998
A new coating method for use in preparing controlled-release beads was developed by modifying the tumbling melt granulation technique. The dissolution rate of the drug from the beads was controlled by coating the mixture of meltable and non-meltable materials by heating in a centrifugal fluidizing granulator without using any solvent.
T, Maejima, T, Osawa, K, Nakajima, M, Kobayashi   +3 more
openaire   +3 more sources

APPLICATION OF HEATING MICROSCOPY ON SINTERING AND MELTING BEHAVIOUR OF NATURAL SANDS OF ARCHAEOLOGICAL INTEREST [PDF]

, 2013
In antiquity, beach sand was one of the main raw materials for glass-making and for the production of other vitreous materials, like Egyptian blue and faience. During the 1st century AD, glass and pigments manufacturing industry was active along the Gulf
Baraldi P., Boschetti C., Hanuskova M., Leonelli C., Miselli P., Montanari F.   +5 more
core  

Production of a new Plant-Based Milk from Adenanthera pavonina seed and evaluation of its nutritional and health Benefits [PDF]

, 2018
A new plant milk was discovered from the seed of Adenanthera pavonina. The physicochemical and nutritional properties of the new pro-milk extract were assessed, and their biochemical effects were compared with those of soy bean extracts.
Adegbite, Olawunmi Adebisi, Afolabi , Israel Sunmola, Ezeoke, Chinemelum Sandra, Martins, Olubukola C., Nwachukwu, C., Olawole, Tolulope Dorcas, Woke, Ruth Chineme   +6 more
core   +2 more sources

Melting and Generation of Micro-Protrusions on Cathode Surface During Spark Conditioning Process in Vacuum [PDF]

, 2022
Spark conditioning is an effective method to increase the dielectric strength in vacuum by melting and removing micro-protrusions on the cathode surface. We aim to optimize the conditioning effect in vacuum for the application of vacuum circuit breakers (
Fukuda, Hideaki, Hayakawa, Naoki, Kita, Naoki, Kojima, Hiroki, Kondo, Fuminori, Yamamura, Kenta   +5 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Effects of Species of Non-meltable and Meltable Materials and Their Physical Properties on Granulatability in Tumbling Melt Granulation Method.

Chemical and Pharmaceutical Bulletin, 1997
Factors affecting granulatabilities in the tumbling melt granulation (TMG) method for the preparation of spherical beads without using any solvent were investigated. Beads of ten kinds of non-meltable materials were prepared using hydrogenated rape oil (HRO) as binder by changing the mixing ratio of the meltable material (X M ), and the recovery ...
Toru MAEJIMA, Takashi OSAWA, Kingo NAKAJIMA, Masao KOBAYASHI   +3 more
openaire   +2 more sources

PENGARUH JENIS KONSENTRASI KOAGULAN TERHADAP MUTU KEJU MOZZARELLA DARI SUSU KAMBING PERANAKAN ETAWA [PDF]

, 2018
Goat milk was popular for health and beauty product. The benefit of goat milk has not been fully realized in food product because of the price quite expensive and the smells of goat milk called “prengus” which most people dislike.
EMMY DIAN RAMADHANI, 133020306, Yusman Taufik, DS   +1 more
core