Results 81 to 90 of about 1,624,941 (389)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reliability of the Method for Establishing Causation between Electrical Circuit Overload and Fire Ignition

Теория и практика судебной экспертизы, 2019
The article presents an analysis of the Russian Federal Centre of Forensic Science of the Russian Ministry of Justice publication ‘Expert study of copper conductors withdrawn from the site of a fre. Learner’s guide’ 2015.
I. S. Taubkin, A. R. Saklantiy
doaj   +1 more source

Vortex-lattice melting in magnesium diboride in terms of the elastic theory

, 2009
In the framework of elastic theory, we study the vortex-lattice melting transitions in magnesium diboride for magnetic fields both parallel and perpendicular to the anisotropy axis.
Angst, Askerzade, Blatter, Bouquet, Brandt, Bud'ko, Carlson, Chen, Cubitt, Eltsev, Fletcher, Herbut, Houghton, Hu, Ivlev, Ivlev, Jian-Ping Lv, Kim, Kortus, Koshelev, Kotegawa, Liu, Lv, McMillan, Nagamatsu, Nie, Pradhan, Qing-Hu Chen, Qing-Miao Nie, Safar, Sologubenko, Wen   +31 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Surface-Induced Phase Transition During Coalescence of Au Nanoparticles: A Molecular Dynamics Simulation Study

, 2019
In this study, the melting and coalescence of Au nanoparticles were investigated using molecular dynamics simulation. The melting points of nanoparticles were calculated by studying the potential energy and Lindemann indices as a function of temperature.
Kamachali, Reza Darvishi
core  

Helix or Coil? Fate of a Melting Heteropolymer

, 2008
We determine the probability that a partially melted heteropolymer at the melting temperature will either melt completely or return to a helix state. This system is equivalent to the splitting probability for a diffusing particle on a finite interval ...
G. Oshanin, Gardiner C. W., Lifshitz I. M., Poland D., Redner S., S. Redner   +5 more
core   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Investigation of fatty acid composition, thermal and rheological behavior of yak, cow and horse fats

MANAS: Journal of Engineering, 2019
The objective of this paper was tostudy the fatty acid composition, and thermal and rheological behavior of Kyrgyz yak (Bos grunniens)visceral fats compared to visceral fats of cow (Bos taurus) and horse (Equuscaballus).
Peter Fischer, Jamila Smanalieva, Zhyldyzai Ozbekova, Asylbek Kulmyrzaev   +3 more
doaj  

Two-component mixture of charged particles confined in a channel: melting

, 2010
The melting of a binary system of charged particles confined in a {\it quasi}-one-dimensional parabolic channel is studied through Monte Carlo simulations. At zero temperature the particles are ordered in parallel chains.
Bedanov V M, Bedanov V M, F M Peeters, Ferreira W P, G A Farias, Kosterlitz J M, Levi B G, Overduin S D, W P Ferreira   +8 more
core   +1 more source