Results 41 to 50 of about 23,537 (218)

Characterization of the Effect of Melt Treatments on Melt Quality in Al-7wt %Si-Mg Alloys

Metals, 2017
The effects of degassing, holding time and melt additions (Sr, Sr + Ti, Ti, B and B + Sr) on the quality of A356 melts were examined. A total of 120 reduced pressure test samples were collected.
Muhammet Uludağ, Remzi Çetin, Derya Dispinar, Murat Tiryakioğlu   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Recent Development in the Investigation on Thermal Conductivity of Silicate Melts

High Temperature Materials and Processes, 2012
Accurate values of thermal conductivity of the silicate melts systematically measured as a function of chemical composition are necessary to understand a mechanism of heat transfer in the silicate melts.
Hasegawa Hiroki, Ohta Hiromichi, Shibata Hiroyuki, Waseda Yoshio   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Alkali Cation-Directed Crystallization: Phase Formation and Thermal Behavior in A₄Ge₉O₂₀ (A = Li, Na, K) Model Systems

Crystals
The structural origin of the germanate anomaly in glasses, which involves complex Ge–O coordination environments, is frequently studied using crystalline analogs.
Elena A. Volkova, Lyubov A. Nevolina, Ekaterina Y. Kotelevskaya, Vladimir L. Kosorukov, Olga N. Koroleva   +4 more
doaj   +1 more source

Chlorine solubility in evolved alkaline magmas

Annals of Geophysics, 2005
Experimental studies of Cl solubility in trachytic to phonolitic melts provide insights into the capacity of alkaline magmas to transport Cl from depth to the earth?s surface and atmosphere, and information on Cl solubility variations with ...
M. R. Carroll
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Approach to NMR Experiments with the Molten Objects Without Solvents

Inventions
This article proposes an approach for acquiring HSQC (Heteronuclear Single Quantum Coherence) spectra using a high-resolution probehead originally designed for solutions.
Ilya Grishanovich, Semyon Shestakov, Semyon Krysanov, Aleksandr Kozhevnikov   +3 more
doaj   +1 more source

Determination of equilibrium state and Sn redox ratio in aluminoborosilicate glass melts by potentiometry and voltammetry

Electrochemistry Communications, 2019
Over the last three decades many studies have reported the investigation of the redox behaviour of multivalent elements (M) in glass melts by voltammetry.
Kicheol Kim, Geunho Choi, Kidong Kim
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source