Results 111 to 120 of about 38,408 (255)
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Clinical trials for rare diseases face a fundamental mathematical challenge that conventional randomized controlled trial (RCT) designs cannot overcome. With approximately 95% of the estimated 10,000–16,000 rare diseases lacking approved therapies, and drug development programs failing at rates exceeding 75% in non‐oncology indications, the ...
Marshall L. Summar, Janet Woodcock
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT In the wake of the ongoing opioid epidemic, the incidence of neonatal opioid withdrawal syndrome (NOWS) has surged. While the short‐term effects of NOWS are well‐characterized, long‐term physiological and molecular consequences remain unclear.
Sara L. Mills‐Huffnagle +4 more
wiley +1 more source
P1–104: Assessing the effects of memantine in APP/PS1 transgenic mice by behavioral studies and ex vivo imaging of amyloid plaques using gadolinium labeled amyloid β peptides and micromri [PDF]
, 2006 Thomas Wısnıewskı +7 more
openalex +1 more source
Clinical Interventions in Aging, 2009 Stuart J Thomas, George T GrossbergDepartment of Neurology and Psychiatry, Saint Louis University School of Medicine, St. Louis, MO, USAAbstract: Memantine is an uncompetitive N-methyl-D-aspartate receptor antagonist with moderate affinity. Its mechanism
Stuart J Thomas, George T Grossberg
doaj
Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function. [PDF]
, 2019 Normal synapse formation is fundamental to brain function. We show here that an apical-basal polarity (A-BP) protein, Lgl1, is present in the postsynaptic density and negatively regulates glutamatergic synapse numbers by antagonizing the atypical protein
Cheng, Hongqiang +12 more
core +1 more source
Efficacy of Memantine for the Depressive Symptoms in Major Mental Diseases: A Systematic Review and Updated Meta-analysis of Randomized Controlled Trials [PDF]
, 2022 Tien‐Wei Hsu +2 more
openalex +1 more source
PLoS ONE, 2012 Although the pathogenic mechanisms that underlie autism are not well understood, there is evidence showing that metabotropic and ionotropic glutamate receptors are hyper-stimulated and the GABAergic system is hypo-stimulated in autism.
Hongen Wei +5 more
doaj +1 more source
Efficacy of memantine in the treatment of fibromyalgia: A double-blind, randomised, controlled trial with 6-month follow-up [PDF]
, 2014 Bárbara Oliván‐Blázquez +9 more
openalex +1 more source
Neuroprotective effects of minocycline on double-stranded RNA-induced neurotoxicity in cultured cortical neurons [PDF]
, 2012 1. Minocycline, memantine,and glycoconjugate were assessed for their ability to protect cultured primary cortical neurons against double-stranded RNA-induced neurotoxicity. 2.
Chang, RCC +6 more
core