Results 101 to 110 of about 38,408 (255)

Neuroprotective Properties of Litchi chinensis and Its Phytochemicals in Preclinical Models of Alzheimer's Disease

Brain and Behavior, Volume 16, Issue 5, May 2026.
ABSTRACT Purpose Alzheimer's disease (AD) is a progressive neurodegenerative disorder involving amyloid‐β deposition, tau hyperphosphorylation, oxidative stress, and neuroinflammation. This review systematically evaluates the neuroprotective effects of Litchi chinensis and its phytochemicals against AD, focusing on modulation of Aβ accumulation, tau ...
Emon Mia, Md. Arif Hossain, Asmaul Husna Bristy, Rakib Hossan, Uzma Asif, Asif Khan Sherwani, Mohammad Y. Alshahrani, Samy Selim, Imam Hossen Rakib, Noshin Tasnim Yana, Khadija Akter, Md. Sakib Al Hasan   +11 more
wiley   +1 more source

Effect of Renal Impairment on the Pharmacokinetics of Memantine

Journal of Pharmacological Sciences, 2012
The effect of renal impairment on the pharmacokinetics of a single oral dose of memantine (10 mg) was determined in Japanese subjects. Subjects were assigned to four groups based on baseline creatinine clearance (CLCR): normal renal function (> 80 mL/min,
Takashi Moritoyo, Tomoko Hasunuma, Kazuhiro Harada, Tomonori Tateishi, Makoto Watanabe, Tsutomu Kotegawa, Masahiro Nagai, Yuji Kumagai, Tomomichi Fujitani, Takahumi Okura, Tomikazu Fukuoka, Kenichi Miyoshi, Bunzo Matsuura, Shinya Furukawa, Tomoe Kobori, Hiroyoko Moritoyo, Noriko Nishikawa, Tomoaki Tsujii, Hirotaka Iwaki, Masahiko Nakamura, Satoshi Makino, Kei Ohnuma, Koichiro Yuji, Megumi Hashimoto, Masaru Takasu, Yutaka Hashizume, Koji You, Tomoko Matsumura, Yuji Tanaka, Nahoko Matsumoto, Junichi Nakamura, Jun Miura, Tadao Akizawa, Kozo Kitazawa, Takanori Shibata, Aki Kuroki, Hirokazu Honda, Masanori Mukai, Kyoichi Ohashi, Takuya Morimoto, Hiromitsu Imai, Toshiaki Okudaira, Fuminori Sato, Junko Imanaga, Katsuhiro Tanaka, Masahiro Nomoto   +45 more
doaj   +1 more source

When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer's Disease. [PDF]

, 2016
Alzheimer\u2019s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists\u2019 attention because of its complexity.
AGOSTINI, MARIO, FASOLATO, CRISTINA
core   +1 more source

A novel multi-target strategy for Alzheimer's disease treatment via sublingual route: Donepezil/memantine/curcumin-loaded nanofibers

, 2022
Fadime Topal, Büşra Ertaş, Ece Güler, Fatmanur Gurbuz, Gul Sinemcan Ozcan, Oguzhan Aydemir, Veysel Gökhan Böcekçı, Gökhan Duruksu, Cansun Sahin Cam, Yusufhan Yazır, Oğuzhan Gündüz, Muhammet Emin Çam   +11 more
openalex   +2 more sources

Efficacy of Dextromethorphan Augmentation in SSRI‐Resistant Obsessive–Compulsive Disorder: A Randomized Controlled Trial

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Obsessive–compulsive disorder (OCD) is a chronic condition associated with marked functional impairment and high rates of treatment resistance. Converging evidence implicates glutamatergic dysregulation in OCD pathophysiology.
Ahmad Zolghadriha, Afagh Anjomshoaa, Romina Bagheri   +2 more
wiley   +1 more source

Xanthatin‐13‐(Pyrrolidine‐2‐Carboxylic Acid), a Sesquiterpene Lactone Isolated From Burdock Leaf, Attenuated Aβ25‐35 Toxicity and Memory Deficits in a Pharmacological Mouse Model of Alzheimer's Disease

Phytotherapy Research, Volume 40, Issue 5, Page 2824-2843, May 2026.
ABSTRACT Alzheimer's disease (AD) is a severe form of dementia, which occurrence increases with age and lifestyle conditions. It is characterized by amyloid protein accumulation forming senile plaques, hyperphosphorylated tau protein forming neurofibrillary tangles, neuroinflammation, and oxidative stress, leading to synapse loss and cell death ...
Charlyne Barry‐Simonnet, Lucie Crouzier, Tristan Moujellil‐Legagneur, Hamza Chaieb‐Errass, Yanis A. Idres, Karine Ferrare, Marc Rolland, Guillaume Cazals, Patrick Poucheret, Tangui Maurice, Didier Tousch   +10 more
wiley   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 402-431, May 2026.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Memantine treatment for Japanese patients with moderate to severe Alzheimer’s disease: a meta-analysis of double-blind, randomized, placebo-controlled trials

Neuropsychiatric Disease and Treatment, 2018
Taro Kishi,1,* Shinji Matsunaga,1,2,* Nakao Iwata1 1Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan; 2Department of Geriatrics and Cognitive Disorders, Fujita Health University School of Medicine ...
Kishi T, Matsunaga S, Iwata N
doaj  

Predicting Response to Pro‐Cognitive Interventions in Mood Disorders: A Systematic Review by the International Society for Bipolar Disorders Targeting Cognition Task Force

Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 374-401, May 2026.
ABSTRACT Introduction Major depressive disorder (MDD) and bipolar disorder (BD) are often associated with persistent cognitive deficits that impair psychosocial functioning. While pro‐cognitive interventions show promise, trial findings are inconsistent, potentially due to baseline factors influencing treatment response.
Dimosthenis Tsapekos, Michail Kalfas, Johanna M. Schandorff, Caterina del Mar Bonnin, Christopher R. Bowie, Vicent Balanzá‐Martínez, Katherine E. Burdick, Andre F. Carvalho, Annemieke Dols, Katie Douglas, Peter Gallagher, Gregor Hasler, Lars V. Kessing, Hanne L. Kjærstad, Beny Lafer, Kathryn E. Lewandowski, Carlos López‐Jaramillo, Anabel Martinez‐Aran, Roger S. McIntyre, Richard J. Porter, Scot E. Purdon, Ayal Schaffer, Paul R. A. Stokes, Tomiki Sumiyoshi, Ivan J. Torres, Tamsyn E. Van Rheenen, Lakshmi N. Yatham, Jeff Zarp, Allan H. Young, Eduard Vieta, Kamilla W. Miskowiak   +30 more
wiley   +1 more source

Therapy of addition for Alzheimer's Disease: combination with galantamine and memantine [PDF]

, 2010
J. Zarra, Luisa Schmidt
openalex   +1 more source