Results 81 to 90 of about 24,117 (172)
Addiction, Volume 121, Issue 11, Page 2897-2958, November 2026.Abstract Background and aims Cocaine use disorder (CUD) is an increasingly widespread concern worldwide. Various pharmacological treatments have been investigated for CUD, but their efficacy remains unclear, and none have been licensed for treatment.
Craig Paterson +13 more
wiley +1 more source
Antitussive effects of memantine in guinea pigs
, 2012 Background: The treatment of cough is a significant clinical unmet need because there is little evidence that current therapies are effective. Based on evidence supporting a role for N-methyl D-aspartate receptors (NMDARs) in cough, we hypothesized that ...
Canning, Brendan J. +7 more
core +1 more source
Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects
European Journal of Neuroscience, Volume 64, Issue 9, November 2026.Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova +2 more
wiley +1 more source
MAGD Trial-Memantine for Agitation in Alzheimer’s Dementia
, 2011 OBJECTIVE: Does memantine improve agitation in dementia DESIGN: Double blind randomized placebo controlled trial SETTING: Nursing Homes PARTICIPANTS: 153 patients with Alzheimer’s dementia INTERVENTION: Memantine vs placebo MEASUREMENTS: Cohen ...
Ballard, Clive G. +18 more
core +1 more source
National Journal of Physiology, Pharmacy and Pharmacology, 2018 Background: Around 510% of patients on selective serotonin reuptake inhibitors discontinue therapy because of side effects. Therefore, research for newer antidepressants with greater effectiveness has to be explored.
Harish G Bagewadi +2 more
doaj +1 more source
The Effects of Memantine on Prepulse Inhibition [PDF]
, 2009 Reduced prepulse inhibition (PPI) of startle provides evidence of deficient sensorimotor gating in several disorders, including schizophrenia. The role of NMDA neurotransmission in the regulation of PPI is unclear, due to cross-species differences in the
N R Swerdlow +9 more
core +1 more source
Memantine increases brain production of kynurenic acid via protein kinase A-dependent mechanism
, 2008 We describe a novel aspect of action of memantine ex vivo, in the brain cortical slices and in vitro, in mixed glial cultures. The drug potently increased the production of kynurenic acid, an endogenous tryptophan metabolite blocking N-methyl-D-aspartate
Kloc, R +4 more
core +1 more source
, 2018 Jinfeng Duan,1,2 Chengming Lao,3,4 Jingkai Chen,1,2 Fen Pan,1,2 Chenlin Zhang,3 Weijuan Xu,1,2 Weihua Zhou,1,2 Jianbo Hu,1,2 Desheng Shang,1 Manli Huang,1,2 Yi Xu1,2 1Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang ...
Huang ML +10 more
core
Altered actions of memantine and NMDA-induced currents in a new Grid2 deleted mouse line
, 2014 An ataxic mouse (12-week-old male) was treated with or without memantine (10 mg/kg). After 10 min, the memantine-treated mouse rolled.
Hiroshi Takemori (662679) +24 more
core +1 more source