Results 71 to 80 of about 17,959 (132)

Memantine: a review of studies into its safety and efficacy in treating Alzheimer’s disease and other dementias

Clinical Interventions in Aging, 2009
Stuart J Thomas, George T GrossbergDepartment of Neurology and Psychiatry, Saint Louis University School of Medicine, St. Louis, MO, USAAbstract: Memantine is an uncompetitive N-methyl-D-aspartate receptor antagonist with moderate affinity. Its mechanism
Stuart J Thomas, George T Grossberg
doaj  

The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome.

PLoS ONE, 2012
Although the pathogenic mechanisms that underlie autism are not well understood, there is evidence showing that metabotropic and ionotropic glutamate receptors are hyper-stimulated and the GABAergic system is hypo-stimulated in autism.
Hongen Wei, Carl Dobkin, Ashfaq M Sheikh, Mazhar Malik, W Ted Brown, Xiaohong Li   +5 more
doaj   +1 more source

The effects of memantine on behavioral disturbances in patients with Alzheimer's disease: a meta-analysis

Neuropsychiatric Disease and Treatment, 2017
Taro Kishi,* Shinji Matsunaga,* Nakao Iwata Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan *These authors contributed equally to this work Background: Memantine is effective in the treatment of behavioral ...
Kishi T, Matsunaga S, Iwata N
doaj  

The Effects of Co-Administration of Memantine And Vitamin D on Spatial Learning and Memory Impairment in Adult Male Rats Model of Alzheimer’s Disease

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2020
Background and Aim: Alzheimer’s disease is the most common causes of dementia among the elderly people. The aim of this study was to evaluate the synergistic effects of memantine and vitamin D on spatial learning and memory impairment in adult male rat ...
Nastaran Zamani, Ahmad Ali Moazedi
doaj  

Memantine for the treatment of frontotemporal dementia: a meta-analysis

Neuropsychiatric Disease and Treatment, 2015
Taro Kishi, Shinji Matsunaga, Nakao Iwata Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan Background: There is no conclusive evidence supporting the efficacy of memantine in frontotemporal dementia (FTD).
Kishi T, Matsunaga S, Iwata N
doaj  

Memantine-induced delayed sleep phase in Huntington’s disease: A case report

Clinical Parkinsonism & Related Disorders
Circadian rhythm sleep disorders may occur after memantine administration. We describe a 49-year-old woman with Huntington’s disease, who complained of sleep onset insomnia following the administration of memantine.
Youshi Fujita, Toshio Hamada, Satoshi Kubota, Tomomi Sakoh-Goshima, Hirotaka Shirasaki   +4 more
doaj   +1 more source

Randomized Placebo-Controlled Trial of Memantine for Smoking Cessation (CCCWFU 99311)

Cancer Control
Introduction Quitting smoking is challenging even with existing pharmacotherapy. Thus, discovery of new cessation medications is imperative. Memantine, a well-tolerated Alzheimer’s disease drug, partially antagonizes glutamate at the N-methyl-D-Aspartate
John Spangler MD, Elizabeth Skidmore MD, Emily V. Dressler PhD, Kathryn E. Weaver PhD, Glenn J. Lesser MD, Gary Burton MD, Benjamin Esparaz MD, Brooke Gillett DO, Edward G. Shaw MD, MA   +8 more
doaj   +1 more source

Effect of Memantine on Positive Sign in Patients with Schizophrenia and Schizoaffective Disorders: A Randomized Double Blind Placebo Controlled Trial

Journal of Mazandaran University of Medical Sciences, 2019
Background and purpose: Memantine is a medication used to treat moderate to severe Alzheimer’s disease. Memantine targeting the glutamatergic system specifically N-Methyl-D-Aspartate offer a novel approach in treatment of psychiatric disorders such as ...
Hamide Abbaspour kasgari, Maria Tavakoli Ardakani, Abdollah Farhadinasab   +2 more
doaj  

Memantine versus Methylphenidate in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical Trial

Iranian Journal of Psychiatry, 2016
Objectives: The aim of this randomized clinical trial was to assess the efficacy of memantine versus methylphenidate in the treatment of children with attention deficit hyperactivity disorder.
MohammadReza Mohammadi, Soleiman Mohammadzadeh, Shahin Akhondzadeh   +2 more
doaj  

State-specific inhibition of NMDA receptors by memantine provides insight into NMDAR channel blocker tolerability. [PDF]

Sci Adv
Phillips MB, Povysheva NV, Neureiter EG, Nigam A, Harnett-Scott KA, Hell JW, Aizenman E, Johnson JW.   +7 more
europepmc   +1 more source