Results 61 to 70 of about 17,959 (132)

Effectiveness of Alcohol Use Disorder Pharmacotherapies by Sex: Systematic Review and Meta‐Analysis

Drug and Alcohol Review, Volume 45, Issue 5, July 2026.
ABSTRACT Issues Alcohol use disorder (AUD) shows sex‐related differences in prevalence, harm and treatment response. Despite growing interest in sex differences, evidence synthesis evaluating pharmacotherapy effectiveness by sex remains limited. Approach Web of Science, PubMed, Scopus, PsycINFO and Cochrane were searched twice.
Juliette Allen, Andrew Jones, Gillian W. Shorter, Catharine Montgomery, Zetta Kougiali, Alina Bagnall, Claire Adshead, Jessie Smith, Sam Burton, Amanda Atkinson, Lillian Guelen, Abigail Rose   +11 more
wiley   +1 more source

Evolving national dementia policies in the OECD: Prevention, diagnosis, and care

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Dementia incurs yearly costs of nearly 1.3 trillion US dollars worldwide, projected to rise significantly in the coming decades due to population aging. This policy review provides an overview of the latest national dementia strategies, diagnostic guidelines, and treatment guidelines across 38 Organisation for Economic Co‐operation and ...
Soohyun Kim, Judit Rauet‐Tejeda, Ricarda Milstein, Jinkook Lee, Ana Llena‐Nozal   +4 more
wiley   +1 more source

The NMDA antagonist memantine affects training induced motor cortex plasticity – a study using transcranial magnetic stimulation [ISRCTN65784760]

BMC Neuroscience, 2005
Background Training of a repetitive synchronised movement of two limb muscles leads to short-term plastic changes in the primary motor cortex, which can be assessed by transcranial magnetic stimulation (TMS) mapping.
Schwenkreis Peter, Witscher Katja, Pleger Burkhard, Malin Jean-Pierre, Tegenthoff Martin   +4 more
doaj   +1 more source

Outcome‐specific risk factors challenge universal dementia prevention priorities: Findings from the Egyptian Dementia Network Registry

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Graphical Abstract illustrating how the different risk factors relate to dementia diagnosis and cognitive performance. Solid arrows indicate robust associations in this cohort; dashed arrows indicate weaker or imprecise associations. Abstract BACKGROUND Dementia prevention targets modifiable factors from high‐income cohorts, but most studies conflate ...
Shimaa A. Heikal, Eman M. Khedr, Gharib Fawi, Mai Othman, Nesma G. Elsheikh, Heba M. Tawfik, Hany I. Hassanin, Sara ElFarrash, Samer Salama, Eman M. Ali, Amna Ibrahim, Ahmed Qayaty, Sara A. Moustafa, Mohamed Salama   +13 more
wiley   +1 more source

The Concentration of Memantine in the Cerebrospinal Fluid of Alzheimer’s Disease Patients and Its Consequence to Oxidative Stress Biomarkers

Frontiers in Pharmacology, 2019
Memantine is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist utilized as a palliative cure for Alzheimer’s disease. This is the second study examining the memantine concentrations in cerebrospinal fluid.
Martin Valis, David Herman, David Herman, Nela Vanova, Nela Vanova, Jiri Masopust, Jiri Masopust, Oldrich Vysata, Jakub Hort, Jakub Hort, Zbysek Pavelek, Blanka Klimova, Kamil Kuca, Jan Misik, Jan Misik, Jana Zdarova Karasova, Jana Zdarova Karasova   +16 more
doaj   +1 more source

Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in AppNL‐G‐F KI mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Whether cholinergic activity in the septohippocampal network affects cognitive dysfunction via hippocampal cholinergic neurostimulating peptide (HCNP) in Alzheimer's pathogenesis remains unclear. METHODS An Alzheimer's pathogenesis by mutation in amyloid‐beta precursor protein gene (AppNL‐G‐F) knock‐in (KI) and HCNP precursor ...
Yo Tsuda, Yuta Madokoro, Kengo Suzuki, Takuya Ooba, Toyohiro Sato, Yuto Uchida, Itsumi Nagai‐Arakawa, Takashi Saito, Hideaki Hara, Hideki Hida, Noriyuki Matsukawa   +10 more
wiley   +1 more source

Development and Validation of a Simple UV–HPLC Method to Quantify the Memantine Drug Used in Alzheimer’s Treatment

Pharmaceuticals
Memantine, a non-competitive NMDA receptor antagonist, is used to treat Alzheimer’s disease. Therefore, loading memantine in nanoparticles (NPs) could be an essential tool to improve the treatment effectiveness while reducing drug toxicity.
Débora Nunes, Tânia G. Tavares, Frenacisco Xavier Malcata, Joana A. Loureiro, Maria Carmo Pereira   +4 more
doaj   +1 more source

Behavioral assessment of antidepressant activity of Memantine - a NMDA receptor antagonist in animal models: An experimental study

National Journal of Physiology, Pharmacy and Pharmacology, 2018
Background: Around 5–10% of patients on selective serotonin reuptake inhibitors discontinue therapy because of side effects. Therefore, research for newer antidepressants with greater effectiveness has to be explored.
Harish G Bagewadi, Rajeshwari, Banderao V Patil   +2 more
doaj   +1 more source

Memantine treatment for Japanese patients with moderate to severe Alzheimer’s disease: a meta-analysis of double-blind, randomized, placebo-controlled trials

Neuropsychiatric Disease and Treatment, 2018
Taro Kishi,1,* Shinji Matsunaga,1,2,* Nakao Iwata1 1Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan; 2Department of Geriatrics and Cognitive Disorders, Fujita Health University School of Medicine ...
Kishi T, Matsunaga S, Iwata N
doaj  

Effect of Renal Impairment on the Pharmacokinetics of Memantine

Journal of Pharmacological Sciences, 2012
The effect of renal impairment on the pharmacokinetics of a single oral dose of memantine (10 mg) was determined in Japanese subjects. Subjects were assigned to four groups based on baseline creatinine clearance (CLCR): normal renal function (> 80 mL/min,
Takashi Moritoyo, Tomoko Hasunuma, Kazuhiro Harada, Tomonori Tateishi, Makoto Watanabe, Tsutomu Kotegawa, Masahiro Nagai, Yuji Kumagai, Tomomichi Fujitani, Takahumi Okura, Tomikazu Fukuoka, Kenichi Miyoshi, Bunzo Matsuura, Shinya Furukawa, Tomoe Kobori, Hiroyoko Moritoyo, Noriko Nishikawa, Tomoaki Tsujii, Hirotaka Iwaki, Masahiko Nakamura, Satoshi Makino, Kei Ohnuma, Koichiro Yuji, Megumi Hashimoto, Masaru Takasu, Yutaka Hashizume, Koji You, Tomoko Matsumura, Yuji Tanaka, Nahoko Matsumoto, Junichi Nakamura, Jun Miura, Tadao Akizawa, Kozo Kitazawa, Takanori Shibata, Aki Kuroki, Hirokazu Honda, Masanori Mukai, Kyoichi Ohashi, Takuya Morimoto, Hiromitsu Imai, Toshiaki Okudaira, Fuminori Sato, Junko Imanaga, Katsuhiro Tanaka, Masahiro Nomoto   +45 more
doaj   +1 more source