Results 41 to 50 of about 17,959 (132)

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Movement Disorders in Developmental and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Monogenic developmental and epileptic encephalopathies (DEE) frequently feature co‐occurring movement disorders. Gene discovery has expanded epilepsy‐dyskinesia syndromes (EDS) from classic associations such as stereotypies in Rett syndrome to PRRT2‐related infantile seizures with paroxysmal dyskinesia and crouched gait in SCN1A ...
Shekeeb Mohammad, Darius Ebrahimi‐Fakhari, Hugo Morales‐Briceno   +2 more
wiley   +1 more source

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats

Behavioural Neurology, 2014
Background. Stress and its consequences are among the causes of accidents. Objective. The effects of intraventral tegmental area (I-VTA) memantine on the plasma corticosterone and eating parameters disturbance induced by acute stress were investigated ...
Zohreh Sadat Nasihatkon, Maryam Khosravi, Zahra Bourbour, Hedayat Sahraei, Mina Ranjbaran, Seyedeh Maryam Hassantash, Mohammad Sahraei, Kefayat Baghlani   +7 more
doaj   +1 more source

Chronic memantine administration prevents ouabain-induced hyperactivity in mice via maintenance of Na+, K+-ATPase activity in the hippocampus

Journal of Pharmacological Sciences, 2019
We have previously reported that mice received intracerebroventricular injection of ouabain, an inhibitor of Na+, K+-ATPase, exhibited hyperactivity via overactivation of glutamatergic neurons.
Yuki Kurauchi, Taishi Yamada, Akinori Hisatsune, Takahiro Seki, Hiroshi Katsuki   +4 more
doaj   +1 more source

Memantine prevents acute stress‐induced memory deficits by reversing sex‐dependent pathophysiological glutamatergic alterations in the dorsal hippocampus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The neural mechanisms underlying effects of acute stress on memory are poorly understood. We demonstrated previously that acute stress produces identical spatial memory deficits in male and female mice but through distinct molecular mechanisms, with females exhibiting up‐regulation of N‐methyl‐D‐aspartate (NMDA) receptor
Sebastiano A. Torrisi, Lidia Diolosà, Giuseppe Aceto, Claudia Marchetti, Federica Geraci, Konstantinos Partsinevelos, Silvia Rizzo, Margherita Grasso, Filippo Caraci, Francesco Bellia, Giovanni Li Volti, Angela Maria Amorini, Marcello D′Ascenzo, Gian Marco Leggio   +13 more
wiley   +1 more source

Interactions of memantine and rivastigmine with graphene oxide nanocarrier and beta-amyloid protein using molecular docking and in-silico methods

Heliyon
Alzheimer's disease is characterized by the accumulation of beta-amyloid plaques and neurofibrillary tangles. Effective therapeutic strategies involve inhibiting the formation of beta-amyloid aggregates and destabilizing existing ones.
Fateme Davoudi, Nasrin Shadjou, Mahdieh Darroudi   +2 more
doaj   +1 more source