Results 41 to 50 of about 24,117 (172)

Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats

Frontiers in Pharmacology, 2019
Alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in learning and memory and are promising targets for pharmacological cognitive enhancement.
Zsolt Kristóf Bali, Zsolt Kristóf Bali, Zsolt Kristóf Bali, Nóra Bruszt, Nóra Bruszt, Sai Ambika Tadepalli, Sai Ambika Tadepalli, Roland Csurgyók, Roland Csurgyók, Lili Veronika Nagy, Lili Veronika Nagy, Márton Tompa, Márton Tompa, István Hernádi, István Hernádi, István Hernádi   +15 more
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Potentiation of general anaesthetic activity of ketamine by memantine [PDF]

, 2019
Background: The study was done with the objective to evaluate synergistic activity of ketamine induced general anesthesia by memantine in wistar albino rats.Methods: The wistar albino rats of either sex were divided into four groups of five animals ...
Umamageswari, M. S., Karthikeyan, T. M., Vasanthan, K.   +2 more
core   +1 more source

Research Trends and Mechanistic Insights Into Natural Medicines for Alzheimer's Disease: A Bibliometric Analysis and Narrative Review

Phytotherapy Research, EarlyView.
Research landscape and mechanistic insights into natural medicines for Alzheimer's disease. ABSTRACT Natural medicines have been widely investigated for Alzheimer's disease (AD), but the development of this field and the relationship between bibliometric themes and experimental evidence remain insufficiently characterized.
Maoning Wang, Xiaolian Zhang, Huaxian Yang, Jianhe Zhao, Wentao Wei, Qian Zhao, Wenjia Wang, Yunhui Hu, Jiansong Fang   +8 more
wiley   +1 more source

Ginsenoside Rh1 Attenuates Alzheimer's Disease‐Like Deficits by Modulating Oxidative Stress and Mitochondrial Dysfunction via SIRT1‐Related Signaling

Phytotherapy Research, EarlyView.
Rh1 attenuates oxidative stress and mitochondrial dysfunction through SIRT1‐related signaling. ABSTRACT Alzheimer's disease (AD) remains a progressive neurodegenerative disorder with limited therapeutic options. Ginsenoside Rh1 has been reported to possess neuroprotective properties, yet its specific role and underlying mechanisms in AD are not fully ...
Shi‐Lu Li, Tao Lin, Wan‐chen Zou, Ya‐jun Wang, Jing‐tian Zhang, Zi Wang, Hong‐yuan Li, Long Chen, Li‐chun Zhao, Shen Ren, Wei Li   +10 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Chronic memantine administration prevents ouabain-induced hyperactivity in mice via maintenance of Na+, K+-ATPase activity in the hippocampus

Journal of Pharmacological Sciences, 2019
We have previously reported that mice received intracerebroventricular injection of ouabain, an inhibitor of Na+, K+-ATPase, exhibited hyperactivity via overactivation of glutamatergic neurons.
Yuki Kurauchi, Taishi Yamada, Akinori Hisatsune, Takahiro Seki, Hiroshi Katsuki   +4 more
doaj   +1 more source

Genetic testing in paediatric neurological disorders

Developmental Medicine &Child Neurology, EarlyView.
In this study 390 paediatric patients with neurological disorders underwent genetic testing via exome sequencing, commercial panel, in‐house epilepsy, and movement disorder gene panels. Exome sequencing provides the highest diagnostic yield, and severe developmental delay and hypotonia predicted pathogenic variants in the exome sequencing cohort ...
Wafa Bani Uraba, Byoung Chan Lee, Shekeeb S. Mohammad, Katrina Fisk, Michael Buckley, Russell C. Dale, Tony Roscioli, Paediatric Neurogenomic Working Group, Manoj P. Menezes, Sachin Gupta, Christopher Troedson, Esther Tantsis, Richard Webster, Bruce Bennetts, Deepak Gill, Kavitha Kothur   +15 more
wiley   +1 more source

Real‐world diagnosis and treatment of individuals with migraine in the United States: The Migraine Insights in Diagnosis and Treatment (MIND) study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The objective of this study was to describe the real‐world diagnosis and treatment patterns of individuals newly diagnosed with migraine in the United States (US). Background Over 10% of adults in the US are living with migraine.
Fred Cohen, Vincent Martin, Avani Patel, Shelby L. Corman, Katie B. Tellor, Meghan Fajardo, D. Cortney Hayflinger, Simon Dagenais   +7 more
wiley   +1 more source

Memantine-induced Myoclonus in a Patient with Alzheimer Disease [PDF]

, 2015
Background: Myoclonus can be a clinical manifestation of numerous neurodegenerative disorders and an adverse drug reaction to medications used in their treatment.Case report: Herein, we report memantine-induced myoclonus in a patient with Alzheimer ...
Mark S. LeDoux, Murgai, Aditya A., Murgai, Aditya A, LeDoux, Mark S., Aditya A. Murgai, LeDoux, Mark S   +5 more
core   +1 more source