Metabolic Kinases as Regulators of Inter-Organelle Communication in Aging and Age-Related Diseases. [PDF]
Chowdhury MR, Jeon JH, Chanda D.
europepmc +1 more source
Holistic therapeutic philosophy: Boost a cascade communication between endoplasmic reticulum-mitochondria-lysosome to overload intracellular Ca<sup>2+</sup> and initiate chemoimmunotherapy. [PDF]
Su Y +6 more
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Small bites for big problems: stepwise aggregate degradation by autophagy. [PDF]
Hipp MS, Mauthe M.
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Organelle-centered resistosome signaling in plant immunity. [PDF]
Wang Q, Yang Y, Zhang L, Chang M.
europepmc +1 more source
Intrinsically Disordered Proteome of Human Membrane‐Less Organelles
AbstractIt is recognized now that various proteinaceous membrane‐less organelles (PMLOs) are commonly found in cytoplasm, nucleus, and mitochondria of various eukaryotic cells (as well as in the chloroplasts of plant cells). Being different from the “traditional” membrane‐encapsulated organelles, such as chloroplasts, endoplasmic reticulum, Golgi ...
Darling, April L. +3 more
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DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles
RNA-dependent DEAD-box ATPases (DDXs) are emerging as major regulators of RNA-containing membrane-less organelles (MLOs). On the one hand, oligomerizing DDXs can promote condensate formation 'in cis', often using RNA as a scaffold. On the other hand, DDXs can disrupt RNA-RNA and RNA-protein interactions and thereby 'in trans' remodel the multivalent ...
Overwijn, Daan, Hondele, Maria
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Photo-dependent membrane-less organelles formed from plant phyB and PIF6 proteins in mammalian cells
International Journal of Biological Macromolecules, 2021Plant photobodies are the membrane-less organelles (MLOs) that can be generated by protein-protein interactions between active form of phytochrome B (phyB) and phytochrome-interacting factors (PIFs). These organelles regulate plant photomorphogenesis.
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The solvent side of proteinaceous membrane-less organelles in light of aqueous two-phase systems
International Journal of Biological Macromolecules, 2018Water represents a common denominator for liquid-liquid phase transitions leading to the formation of the polymer-based aqueous two-phase systems (ATPSs) and a set of the proteinaceous membrane-less organelles (PMLOs). ATPSs have a broad range of biotechnological applications, whereas PMLOs play a number of crucial roles in cellular ...
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