Results 211 to 220 of about 5,515,438 (264)

An activity-modulated transport route across myelin (TRAM) for motor-driven organelle transfer in oligodendrocytes. [PDF]

Nat Neurosci
Chapple KJ, Green TRF, Schuster KH, Wirth S, Chen YH, Gerwig UC, Aicher ML, Kim Y, Komarek L, Brown A, Crawford CL, Sherrard Smith R, Lee JY, Black LE, Pardo L, McHugh RE, Kassmann CM, Möbius W, Werner HB, Davis I, Kneussel M, Hughes EG, Brown ER, Goebbels S, Nave KA, Edgar JM.   +25 more
europepmc   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

Hydration‐Gated Photoinduced Electron Transfer in BODIPY Dyes

Angewandte Chemie, EarlyView.
Hydration switches photoinduced electron transfer (PET) ON in alkoxy‐coordinated BODIPY dyes via specific hydrogen bonding. This gating yields a fluorescence lifetime span of ∼6 ns, enabling fluorescence lifetime imaging microscopy (FLIM) contrast in live cells and organoids. ABSTRACT Fluorescent probes based on photoinduced electron transfer (PET) are
Venkata N. K. Mamillapalli, Irina A. Okkelman, Fatima Akhssas, Greta Sambucari, Angela C. Debruyne, Dinesh Beniwal, Christophe Bucher, Mariangela Di Donato, Ruslan I. Dmitriev, Mikhail A. Filatov   +9 more
wiley   +2 more sources

A human lysosomal storage disorder toolkit for decoding proteome landscapes in cortical-like and dopaminergic-like induced neurons. [PDF]

Proc Natl Acad Sci U S A
Kraus F, He Y, Jiang Y, Li D, Ambaw YA, Gasparoli FM, Paulo JA, Walther TC, Farese RV, Gygi SP, Wilfling F, Harper JW.   +11 more
europepmc   +1 more source

In Vivo Nb4C3Tx MXene‐Assisted Photothermal Therapy of Melanoma in Mice

Advanced NanoBiomed Research, EarlyView.
Nb4C3Tx MXene converts pulsed 1064 nm irradiation into localized heat, producing concentration‐ and time‐dependent melanoma cell killing in vitro and suppressing tumor growth in mice. Histology reveals extensive tumor damage, macrophage‐associated material clearance, and no detectable persistent deposits in examined visceral organs, supporting Nb4C3Tx ...
Anton Roshchupkin, Benjamin Chacon, Gulnaz Gahramanova, Inna Chorna, Zhanna Klishchova, Anastasia Konieva, Ilya Yanko, Andrii Liutyi, Milena Yalyzhko, Ivan Baginskiy, Veronika Zahorodna, Júlio Sílvio de Sousa Bueno Filho, Erfan Rezvani Ghomi, Igor Panko, Tetiana Shapochka, Oksana Sulaieva, Oleksandr Solodovnyk, Lucia Gemma Delogu, Oleksiy Gogotsi, Laura Fusco, Sergiy Kyrylenko, Yury Gogotsi, Maksym Pogorielov   +22 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Spatial Coupling of Viral RNA Translation and Replication in Zika Infection. [PDF]

ACS Omega
Zheng G, Li Y, He X, Tao Y, Zhang J, Zhang L, Chen M, Cai P, Cho WC, Zheng Y, Zhang X.   +10 more
europepmc   +1 more source

Modeling Parkinson's pathology in human iPSC dopaminergic neurons uncovers key mechanisms of Lewy body formation and heterogeneity. [PDF]

Sci Adv
Mahul-Mellier AL, van den Heuvel L, Teixeira M, Boussouf MLN, Oudinot G, Thonet A, Speri D, Jasiqi Y, Ulrich C, Sheta R, Idi W, Croisier M, Clerc-Rosset S, Blanc J, Knott G, Oueslati A, Lashuel HA.   +16 more
europepmc   +1 more source

PERSPECTIVE: organelle positioning as a principle of metabolic regulation and stress tolerance. [PDF]

Plant J
Fernie AR, Decros G, Multhoff J, Sippel J, Niemeier JO, Barreto P, Sampathkumar A, Sonnewald U, Schwarzländer M.   +8 more
europepmc   +1 more source

The Role of Autophagy in the Pathogenesis of Mitochondrial Diseases. [PDF]

Cells
Avdonina ED, Kutsev SI, Shestopalov AV.
europepmc   +1 more source