Results 91 to 100 of about 5,071,260 (360)
By analysing supersymmetry transformations we derive new BPS equations for the D=11 fivebrane propagating in flat space that involve the world-volume three-form. The equations generalise those of 2,3,4 and 5 dimensional special Lagrangian submanifolds and are relevant for describing membranes ending on these submanifolds.
openaire +2 more sources
ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation
Fine-tuning pyroptosis with ESCRT-III Pyroptosis is an inflammatory form of cell death induced by select caspases downstream of inflammasome complexes. These caspases cleave gasdermin D (GSDMD), whose N-terminal fragments quickly form large permeability ...
S. Rühl+5 more
semanticscholar +1 more source
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter+8 more
wiley +1 more source
β/γ-Crystallins are predominant structural proteins in the cytoplasm of lens fiber cells and share a similar fold composing of four Greek-key motifs divided into two domains.
Liang-Bo Qi+5 more
doaj +1 more source
Controllable ion transport by surface-charged graphene oxide membrane
Ion transport is crucial for biological systems and membrane-based technology. Atomic-thick two-dimensional materials, especially graphene oxide (GO), have emerged as ideal building blocks for developing synthetic membranes for ion transport.
Mengchen Zhang+5 more
semanticscholar +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li+3 more
wiley +1 more source
Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
Fas is a death receptor that regulates apoptosis in many cell types and is downregulated on the cell surface in many cancers. Here, Sharma et al. show that endosome associated trafficking regulator ENTR1 regulates delivery of Fas to lysosomes, thereby ...
Shruti Sharma+8 more
doaj +1 more source
Glycolipids (such as glycoglycerolipids, glycosphingolipids, and glycosylphosphatidylinositol) and lipoglycans (such as lipopolysaccharides (LPS), lipooligosaccharides (LOS), mycobacterial lipoarabinomannan, and mycoplasma lipoglycans) are typically ...
Jumin Lee+15 more
semanticscholar +1 more source
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin+14 more
wiley +1 more source
Membrane systems with proteins embedded in membranes
Membrane computing is a biologically inspired computational paradigm. Motivated by brane calculi we investigate membrane systems which differ from conventional membrane systems by the following features: (1) biomolecules (proteins) can move through the regions of the systems, and can attach onto (and de-attach from) membranes, and (2 ...
Brijder R.+4 more
openaire +3 more sources