Results 111 to 120 of about 6,029,360 (328)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Generation of motional nonlinear coherent states and their superpositions via intensity-dependent coupling of a cavity field to a micromechanical membrane

open access: yes, 2011
We propose a theoretical scheme to show the possibility of generating motional nonlinear coherent states and their superposition for an undamped vibrating micromechanical membrane inside an optical cavity.
Barzanjeh, Sh.   +2 more
core   +1 more source

Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95

open access: yesNature Communications, 2019
Fas is a death receptor that regulates apoptosis in many cell types and is downregulated on the cell surface in many cancers. Here, Sharma et al. show that endosome associated trafficking regulator ENTR1 regulates delivery of Fas to lysosomes, thereby ...
Shruti Sharma   +8 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Cataract-causing mutation S228P promotes βB1-crystallin aggregation and degradation by separating two interacting loops in C-terminal domain

open access: yesProtein & Cell, 2016
β/γ-Crystallins are predominant structural proteins in the cytoplasm of lens fiber cells and share a similar fold composing of four Greek-key motifs divided into two domains.
Liang-Bo Qi   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The effect of flower-like tatania towards characteristics and performance of polysulfone mixed matrix membrane [PDF]

open access: yes, 2018
For ages, the polymeric membrane such as PSf is widely used in liquid separation for various application as the polymer itself offer versatile and attractive properties.
Azhar, Mohd Faiz Hafeez
core  

How the electromagnetic field evolves in the presence of a mobile membrane

open access: yes, 2016
We consider a one-dimensional cavity composed of two perfect, fixed mirrors and a mobile membrane in between. Assuming that the membrane starts to move from rest and that the membrane moves appreciably in a time-scale much larger than the time-scale in ...
Castaños, L. O., Weder, R.
core   +1 more source

Fouling-resistant reverse osmosis membranes grafted with 2-aminoethanethiol having a low interaction energy with charged foulants

open access: yesnpj Clean Water
Many fouling-resistant materials have been grafted or coated on the RO membrane surface for fouling-resistance. However, these modified RO membranes still exhibit a fast flux drop towards small charged organic foulants.
Jun Xiao   +5 more
doaj   +1 more source

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