Results 61 to 70 of about 6,029,360 (328)

The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes

Communications Biology, 2023
In arterial myocytes, the canonical function of voltage-gated CaV1.2 and KV2.1 channels is to induce myocyte contraction and relaxation through their responses to membrane depolarization, respectively.
Collin Matsumoto, Samantha C. O’Dwyer, Declan Manning, Gonzalo Hernandez-Hernandez, Paula Rhana, Zhihui Fong, Daisuke Sato, Colleen E. Clancy, Nicholas C. Vierra, James S. Trimmer, L. Fernando Santana   +10 more
doaj   +1 more source

Membrane Fusion [PDF]

Cell, 2003
Membrane fusion, one of the most fundamental processes in life, occurs when two separate lipid membranes merge into a single continuous bilayer. Fusion reactions share common features, but are catalyzed by diverse proteins. These proteins mediate the initial recognition of the membranes that are destined for fusion and pull the membranes close together
Jahn, R., Lang, T., Suedhof, T.
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Biosynthesis of Mitochondrial Porin and Insertion into the Outer Mitochondrial Membrane of Neuruspora crassa [PDF]

, 1982
Mitochondrial porin, the major protein of the outer mitochondrial membrane is synthesized by free cytoplasmic polysomes. The apparent molecular weight of the porin synthesized in homologous or heterologous cell-free systems is the same as that of the ...
Cassady W. E., Colombini M., Conboy J. G., Cote C., Cowlesmith I., Freitag H., Glizin V., Hallermayer R., Hennig B., Korb H., Lewin A., Maccecchini M. L., Maccechini M. L., Matsuura S., Mihara K., Nabi N., Nelson N., Neupert W., Oda T., Palmiter R. D., Payvar F., Raymond Y., Scheele G., Schleyer M., Schmelzer E., Sebald W., Sherton C. C., Shore G. C., Sonderegger P., Teintze M., Ullrich A., Zelman L. S., Zimmermann R., Zimmermann R., Zimmermann R., Zimmermann R.   +35 more
core   +1 more source

A Peptide‐Derived Aggregation‐Induced Emission Nanobioprobe: Unlocking Selective Detection of Fusobacterium nucleatum and Noninvasive Screening of Colorectal Cancer

Aggregate
Colorectal cancer (CRC) screening and early diagnosis is an effective strategy for reducing CRC mortality. However, the current detection methods involve exorbitant costs and complex procedures, which are inconvenient for large‐scale screening. Given its
Hongyu Liu, Tengling Wu, Yunjian Yu, Youtao Xin, Hegang Lu, Shengke Zhao, Meihui Su, Lu Ga, Alideertu Dong, Mahmoud Elsabahy, Hui Gao   +10 more
doaj   +1 more source

Ionic Liquid Confined in Mesoporous Polymer Membrane with Improved Stability for CO2/N2 Separation

Nanomaterials, 2017
Supported ionic liquid membranes (SILMs) have a promising prospect of application in flue gas separation, owing to its high permeability and selectivity of CO2.
Ming Tan, Jingting Lu, Yang Zhang, Heqing Jiang   +3 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Receptor-Mediated Endocytosis of a Cylindrical Nanoparticle in the Presence of Cytoskeleton Substrate

, 2019
Internalization of particles by cells plays a crucial role for adsorbing nutrients and fighting infection. Endocytosis is one of the most important mechanisms of the particles uptake which encompass multiple pathways.
Khosravanizadeh, Amir, Mohammad-Rafiee, Farshid, Sens, Pierre   +2 more
core   +1 more source

RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells

Molecular Systems Biology, 2012
The Golgi apparatus has many important physiological functions, including sorting of secretory cargo and biosynthesis of complex glycans. These functions depend on the intricate and compartmentalized organization of the Golgi apparatus.
Joanne Chia, Germaine Goh, Victor Racine, Susanne Ng, Pankaj Kumar, Frederic Bard   +5 more
doaj   +1 more source

Modelling of Ion Transport in Electromembrane Systems: Impacts of Membrane Bulk and Surface Heterogeneity

Applied Sciences, 2018
Artificial charged membranes, similar to the biological membranes, are self-assembled nanostructured materials constructed from macromolecules.
Victor Nikonenko, Andrey Nebavsky, Semyon Mareev, Anna Kovalenko, Mahamet Urtenov, Gerald Pourcelly   +5 more
doaj   +1 more source