Results 91 to 100 of about 165,835 (261)

Lateral diffusion of a protein on a fluctuating membrane

, 2005
Measurements of lateral diffusion of proteins in a membrane typically assume that the movement of the protein occurs in a flat plane. Real membranes, however, are subject to thermal fluctuations, leading to movement of an inclusion into the third ...
Aizenbud B. M., Dan N., Doi M., E Reister, Goulian M., Lipowsky R., Netz R. R., U Seifert, Vrljic M.   +8 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Enhancement of cell membrane invaginations, vesiculation and uptake of macromolecules by protonation of the cell surface. [PDF]

PLoS ONE, 2012
The different pathways of endocytosis share an initial step involving local inward curvature of the cell's lipid bilayer. It has been shown that to generate membrane curvature, proteins or lipids enforce transversal asymmetry of the plasma membrane. Thus
Nadav Ben-Dov, Rafi Korenstein
doaj   +1 more source

Capture on High Curvature Region: Aggregation of Colloidal Particle Bound to Giant Phospholipid Vesicles

, 1999
A very recent observation on the membrane mediated attraction and ordered aggregation of colloidal particles bound to giant phospholipid vesicles (I. Koltover, J. O. R\"{a}dler, C. R. Safinya, Phys. Rev. Lett.
Helfrich W., JI-XING LIU, Naito H., Ou-Yang Z.-C., QUAN-HUI LIU, Sackman E., ZHONG-CAN OU-YANG   +6 more
core   +2 more sources

Membrane-Mediated Aggregation of Curvature-Inducing Nematogens and Membrane Tubulation [PDF]

Biophysical Journal, 2013
The shapes of cell membranes are largely regulated by membrane associated, curvature active, proteins. We use a numerical model of the membrane with elongated membrane inclusions, recently developed by us, which posses spontaneous directional curvatures that could be different along and perpendicular to its long axis.
Ramakrishnan, N., Sunil Kumar, P.B., Ipsen, John H.   +2 more
openaire   +4 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Two- or three-step assembly of banana-shaped proteins coupled with shape transformation of lipid membranes

, 2014
BAR superfamily proteins have a banana-shaped domain that causes the local bending of lipid membranes. We study as to how such a local anisotropic curvature induces effective interaction between proteins and changes the global shape of vesicles and ...
Noguchi, Hiroshi
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Composition based strategies for controlling radii in lipid nanotubes. [PDF]

PLoS ONE, 2014
Nature routinely carries out small-scale chemistry within lipid bound cells and organelles. Liposome-lipid nanotube networks are being developed by many researchers in attempt to imitate these membrane enclosed environments, with the goal to perform ...
Michael E Kurczy, Lisa J Mellander, Neda Najafinobar, Ann-Sofie Cans   +3 more
doaj   +1 more source

Gating-by-tilt of mechanosensitive membrane channels

, 2003
We propose an alternative mechanism for the gating of biological membrane channels in response to membrane tension that involves a change in the slope of the membrane near the channel. Under biological membrane tensions we show that the energy difference
A. Kloda, A. N. J. A. Ridder, B. Alberts, B. Calabrese, B. Martinac, I. V. Tabarean, J. Gullingsrud, J. M. Wood, M. Goulian, Matthew S. Turner, O. P. Hamill, Pierre Sens, R. S. Cantor, S. A. Safran, S. I. Sukharev, S. I. Sukharev   +15 more
core   +1 more source