Results 91 to 100 of about 165,610 (282)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Enhancement of cell membrane invaginations, vesiculation and uptake of macromolecules by protonation of the cell surface. [PDF]

PLoS ONE, 2012
The different pathways of endocytosis share an initial step involving local inward curvature of the cell's lipid bilayer. It has been shown that to generate membrane curvature, proteins or lipids enforce transversal asymmetry of the plasma membrane. Thus
Nadav Ben-Dov, Rafi Korenstein
doaj   +1 more source

Shapes of pored membranes

, 2012
We study the shapes of pored membranes within the framework of the Helfrich theory under the constraints of fixed area and pore size. We show that the mean curvature term leads to a budding- like structure, while the Gaussian curvature term tends to ...
de la Cruz, Monica Olvera, Sknepnek, Rastko, Thomas, Creighton K., Yao, Zhenwei   +3 more
core   +1 more source

Membrane-Mediated Aggregation of Curvature-Inducing Nematogens and Membrane Tubulation [PDF]

Biophysical Journal, 2013
The shapes of cell membranes are largely regulated by membrane associated, curvature active, proteins. We use a numerical model of the membrane with elongated membrane inclusions, recently developed by us, which posses spontaneous directional curvatures that could be different along and perpendicular to its long axis.
Ramakrishnan, N., Sunil Kumar, P.B., Ipsen, John H.   +2 more
openaire   +4 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Theory of Cylindrical Tubules and Helical Ribbons of Chiral Lipid Membranes

, 1995
We present a general theory for the equilibrium structure of cylindrical tubules and helical ribbons of chiral lipid membranes. This theory is based on a continuum elastic free energy that permits variations in the direction of molecular tilt and in the ...
A. E. Jacobs, A. S. Rudolph, A. Singh, A. Tardieu, B. M. Peek, B. N. Thomas, C.-M. Chen, C.-M. Chen, D. R. Nelson, D. S. Chung, E. Sackmann, F. C. MacKintosh, F. C. MacKintosh, G. A. Hinshaw, G. A. Hinshaw, H. S. Seung, J. A. N. Zasadzinski, J. H. Georger, J. M. Schnur, J. M. Schnur, J. M. Schnur, J. S. Chappell, J. S. Chappell, J. V. Selinger, J. V. Selinger, M. A. Markowitz, M. Markowitz, N. Nakashima, P. Nelson, P. Yager, P. Yager, P. Yager, P.-G. de Gennes, R. Shashidhar, R. Treanor, S. A. Langer, S. L. Brandow, S. L. Burkett, T. C. Lubensky, T. C. Lubensky, T. Tachibana, W. Helfrich, W. Helfrich, X. Qiu   +43 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Lateral diffusion of a protein on a fluctuating membrane

, 2005
Measurements of lateral diffusion of proteins in a membrane typically assume that the movement of the protein occurs in a flat plane. Real membranes, however, are subject to thermal fluctuations, leading to movement of an inclusion into the third ...
Aizenbud B. M., Dan N., Doi M., E Reister, Goulian M., Lipowsky R., Netz R. R., U Seifert, Vrljic M.   +8 more
core   +1 more source

Arabidopsis CURVATURE THYLAKOID1 Proteins Modify Thylakoid Architecture by Inducing Membrane Curvature [PDF]

The Plant Cell, 2013
Chloroplasts of land plants characteristically contain grana, cylindrical stacks of thylakoid membranes. A granum consists of a core of appressed membranes, two stroma-exposed end membranes, and margins, which connect pairs of grana membranes at their lumenal sides.
Armbruster, Ute, Labs, Mathias, Pribil, Mathias, Viola, Stefania, Xu, Wenteng, Scharfenberg, Michael, Hertie, Alexander P., Rojahn, Ulrike, Jensen, Poul Erik, Rappaport, Fabrice, Joliot, Pierre, Dörmann, Peter, Wanner, Gerhard, Leister, Dario   +13 more
openaire   +5 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source