Results 21 to 30 of about 165,835 (261)
Mechanism of membrane-curvature generation by ER-tubule shaping proteins
Nature Communications, 2021 The endoplasmic reticulum network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs, but how they introduce curvature is poorly understood.
Ning Wang +5 more
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Monomeric Synucleins Generate Membrane Curvature [PDF]
Journal of Biological Chemistry, 2013 Synucleins are a family of presynaptic membrane binding proteins. α-Synuclein, the principal member of this family, is mutated in familial Parkinson disease. To gain insight into the molecular functions of synucleins, we performed an unbiased proteomic screen and identified synaptic protein changes in αβγ-synuclein knock-out brains.
Christopher H, Westphal +1 more
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Membrane curvature response in autophagy [PDF]
Autophagy, 2011 Membrane trafficking is key for signal transduction, cargo transportation, and in the case of autophagy, delivering cytoplasmic substrates to the lysosome for degradation. Autophagy requires the formation of a unique double membrane vesicle, the autophagosome. However, the mechanism by which the autophagosome forms is unknown.
Livia, Wilz, Weiliang, Fan, Qing, Zhong
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Sensing Membrane Curvature in Macroautophagy [PDF]
Journal of Molecular Biology, 2017 In response to intracellular stress events ranging from starvation to pathogen invasion, the cell activates one or more forms of macroautophagy. The key event in these related pathways is the de novo formation of a new organelle called the autophagosome, which either surrounds and sequesters random portions of the cytoplasm or selectively targets ...
Nathan, Nguyen +2 more
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Modeling curvature-dependent subcellular localization of the small sporulation protein SpoVM in Bacillus subtilis. [PDF]
PLoS ONE, 2015 Recent in vivo experiments suggest that in the bacterium, Bacillus subtilis, the cue for the localization of the small sporulation protein, SpoVM, an essential factor in spore coat formation, is curvature of the bacterial plasma membrane.
Vaibhav Wasnik +2 more
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Amphipathic helices and membrane curvature [PDF]
FEBS Letters, 2009 Numerous data have been collected on lipid‐binding amphipathic helices involved in membrane‐remodeling machineries and vesicular transport. Here we describe how, with regard to lipid composition, the physicochemical features of some amphipathic helices explain their ability to recognize membrane curvature or to participate in membrane remodeling.
Drin, Guillaume, Antonny, Bruno
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Arf1 and membrane curvature cooperate to recruit Arfaptin2 to liposomes. [PDF]
PLoS ONE, 2013 Arfaptin2 contains a Bin/Amphiphysin/Rvs (BAR) domain and directly interacts with proteins of the Arf/Arl family in their active GTP-bound state. It has been proposed that BAR domains are able to sense membrane curvature and to induce membrane tubulation.
Ernesto E Ambroggio +4 more
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Curvature dependence of BAR protein membrane association and dissociation kinetics
Scientific Reports, 2022 BAR (Bin/Amphiphysin/Rvs) domain containing proteins function as lipid bilayer benders and curvature sensors, and they contribute to membrane shaping involved in cell signaling and metabolism.
Rui Jin, Rui Cao, Tobias Baumgart
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Membrane curvature controls dynamin polymerization [PDF]
Proceedings of the National Academy of Sciences, 2010 The generation of membrane curvature in intracellular traffic involves many proteins that can curve lipid bilayers. Among these, dynamin-like proteins were shown to deform membranes into tubules, and thus far are the only proteins known to mechanically drive membrane fission.
Roux, Aurelien +6 more
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iScience, 2020 Summary: Membrane curvature has emerged as an intriguing physical principle underlying biological signaling and membrane trafficking. The CIP4/FBP17/Toca-1 F-BAR subfamily is unique in the BAR family because its structurally folded F-BAR domain does not ...
Maohan Su +6 more
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