Results 151 to 160 of about 2,200,142 (368)
Advanced Science, EarlyView.By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley +1 more source
α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
Advanced Science, EarlyView.A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro +14 more
wiley +1 more source
Analysis &Sensing, Volume 3, Issue 1, January 2023., 2023 Lanthanide complexes are ideal donors for FRET (Förster resonance energy transfer) assays with a variety of applications from easy‐to‐use quantitation of proteins to sophisticated experiments giving real‐time information on the movement of proteins. This Review article introduces the principles of using such assays before surveying the full scope of ...
Simon Wheeler, Stephen J. Butler
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Intestinal Epithelial Cell Surface Membrane Glycoprotein Synthesis
, 1973 Milton M. Weiser
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Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury
Advanced Science, EarlyView.Based on the biodegradability and the immunological reactiveness, IMNs can be broadly classified into four categories. The first category includes types of biologically derived materials that cause immunomodulatory action and biodegradability like nanoparticles of cell membranes, extracellular vesicles, and exosomes.
Chenli Zhang +5 more
wiley +1 more source
Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies
Advanced Science, EarlyView.Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu +7 more
wiley +1 more source
Structural polymorphism within the amino-terminal region of MM, NN, and MN glycoproteins (glycophorins) of the human erythrocyte membrane [PDF]
, 1978 Olga O. Blumenfeld, Anthony M. Adamany
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Advanced Science, EarlyView.Migrasomes are newly discovered organelles in migrating cells. This study finds that osteosarcoma cell‐derived migrasomes promote the tumor‐promoting phenotype of macrophages and further aggravate osteosarcoma malignant progression via milk fat globule‐EGF factor 8.
Wanshun Liu +10 more
wiley +1 more source
BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Drug repurposing has the potential to accelerate the discovery of TMPRSS2 inhibitors acting as COVID‐19 antivirals. In this regard, a low throughput screening led to the identification of BC‐11 as a covalent TMPRSS2 fragment inhibitor (IC50 = 1.44 µM), displaying significant SARS‐CoV‐2 entry inhibition (EC50 = 66 µM). Abstract Host cell entry of severe
Aurélien F. A. Moumbock +3 more
wiley +1 more source
Synthesis of membrane glycoproteins in rat small-intestinal villus cells. Effect of colchicine on the redistribution of
, 1979 Andrea Quaroni +2 more
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