Results 101 to 110 of about 433,130 (308)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Protein-lipid interactions: paparazzi hunting for snap-shots

, 2009
Photoactivatable groups meeting the criterion of minimal perturbance allow the investigation of interactions in biological samples. Here, we review the application of photoactivatable groups in lipids enabling the study of protein-lipid interactions in ...
Sub Membrane Enzymology begr. 01-06-12, van Meer, G., Haberkant, P., Membrane Enzymology   +3 more
core   +1 more source

Aggregation modulators interfere with membrane interactions of beta2-microglobulin fibrils. [PDF]

, 2013
Amyloid fibril accumulation is a pathological hallmark of several devastating disorders, including Alzheimer's disease, prion diseases, type II diabetes, and others.
Xue, Wei-Feng, Xue, W-F, Sheynis, Tania, Sheynis, T, Radford, Sheena E., Tipping, KW, Radford, SE, Hellewell, AL, Jelinek, Raz, Friediger, Anat, Friediger, A, Tipping, Kevin W., Hellewell, Andrew L., Hewitt, Eric W., Tipping, Kevin W, Hewitt, EW, Jelinek, R   +16 more
core   +1 more source

Exploring robustness of hybrid membranes under high hydrostatic pressure and temperature

Frontiers in Microbiology
Bacterial membranes are typically composed of ester-bonded fatty acid (FA), while archaeal membranes consist of ether-bonded isoprenoids, differentiation referred to as the ‘lipid divide’.
Anandi Tamby, Diana X. Sahonero-Canavesi, Laura Villanueva, Laura Villanueva   +3 more
doaj   +1 more source

Importance of the hexagonal lipid phase in biological membrane organisation

Frontiers in Plant Science, 2013
:Domains are present in every natural membrane. They are characterised by a distinctive protein and/or lipid composition. Their size is highly variable from the nano- to the micrometer scale. The domains confer specific properties to the membrane leading
Juliette eJouhet, Juliette eJouhet, Juliette eJouhet, Juliette eJouhet   +3 more
doaj   +1 more source

Imaging the rapid yet transient accumulation of regulatory lipids, lipid kinases, and protein kinases during membrane fusion, at sites of exocytosis of MMP-9 in MCF-7 cells

Lipids in Health and Disease, 2020
Background The regulation of exocytosis is physiologically vital in cells and requires a variety of distinct proteins and lipids that facilitate efficient, fast, and timely release of secretory vesicle cargo.
Dominique C. Stephens, Tyrel W. Powell, Justin W. Taraska, Dinari A. Harris   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Interaction of Hematoporphyrin with Lipid Membranes

The Journal of Physical Chemistry B, 2012
Natural or synthetic porphyrins are being used as photosensitizers in photodiagnosis (PD) and photodynamic therapy (PDT) of malignancies and some other diseases. Understanding the interactions between porphyrins and cell membranes is therefore important to rationalize the uptake of photosensitizers and their passive transport through cell membranes. In
M. Stepniewski, M. Kepczynski, D. Jamroz, M. Nowakowska, S. Rissanen, I. Vattulainen, and T. Rog   +6 more
openaire   +5 more sources

The fate and function of glycosphingolipid glucosylceramide

, 2003
In higher eukaryotes, glucosylceramide is the simplest member and precursor of a fascinating class of membrane lipids, the glycosphingolipids.
Degroote, S., Wolthoorn, J., van Meer, G., Membraan enzymologie, Membrane Enzymlogy 1, Dep Scheikunde, Membrane Enzymology   +6 more
core   +1 more source