Results 121 to 130 of about 1,682,039 (300)

Lipid–Protein Interplay in the Regulation of Receptor Tyrosine Kinases

Cells
Receptor tyrosine kinases (RTKs), a class of membrane proteins involved in several physiological processes such as growth, survival, angiogenesis, and differentiation, are profoundly influenced by the microenvironment, particularly by surrounding lipids.
Mattia Domenichini, Anna Gogna, Camilla Maggi, Elisa Moreschi, Anna Ventura, Martina Codibue, Elisabetta Grillo, Michela Corsini, Stefania Mitola   +8 more
doaj   +1 more source

Polymerization from Lipid Membranes

Biomacromolecules
In living cells, lipid bilayer membranes can be asymmetrically functionalized, with brush-like layers of macromolecules. These coatings, like the glycocalyx, often originate from the membrane and feature high surface concentrations. Yet in vitro, synthetic methods used to functionalize lipid membranes with macromolecules typically graft presynthesized ...
Alexandre L. Torzynski, Dominique Grimm, Matteo Romio, Claire François-Martin, Hendrik Spanke, Gianna Wolfisberg, Margarita Staykova, Edmondo M. Benetti, Eric R. Dufresne   +8 more
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Digalactosyl-diacylglycerol-deficiency lowers the thermal stability of thylakoid membranes [PDF]

, 2010
We investigated the effects of digalactosyl-diacylglycerol (DGDG) on the organization and thermal stability of thylakoid membranes, using wild-type Arabidopsis thaliana and the DGDG-deficient mutant, dgd1. Circular-dichroism measurements reveal that DGDG-
Tünde Tóth, Győző Garab, van Amerongen, H., Laptenok, S., Amerongen, H., van, Sashka Boychova Krumova, László Kovács, Garab, G., Hoek, A., van, Toth, T., Arie van Hoek, van Hoek, A., Sergey Petrovich Laptenok, Krumova, S.K.B., Kovács, L., Herbert van Amerongen   +15 more
core   +1 more source

Impaired lipid homeostasis and elevated lipid oxidation of erythrocyte membrane in adolescent depression

Redox Biology
Adolescent depression is a globally concerned mental health issue, the pathophysiological mechanisms of which remain elusive. Membrane lipids play a crucial role in brain development and function, potentially serving as a crossroad for the abnormalities ...
Jinfeng Wang, Xiaowen Hu, Ya Li, Shuhui Li, Tianqi Wang, Dandan Wang, Yan Gao, Qian Wang, Jiansong Zhou, Chunling Wan   +9 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Mobile and Immobile Obstacles in Supported Lipid Bilayer Systems and Their Effect on Lipid Mobility

Colloids and Interfaces
Diffusion and immobilization of molecules in biomembranes are essential for life. Understanding it is crucial for biomimetic approaches where well-defined substrates are created for live cell assays or biomaterial development. Here, we present biomimetic
Luisa Coen, Daniel Alexander Kuckla, Andreas Neusch, Cornelia Monzel   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The styrene-maleic acid copolymer:: a versatile tool in membrane research [PDF]

, 2016
A new and promising tool in membrane research is the detergent-free solubilization of membrane proteins by styrene-maleic acid copolymers (SMAs). These amphipathic molecules are able to solubilize lipid bilayers in the form of nanodiscs that are bounded ...
Sub Membrane Biochemistry & Biophysics, Scheidelaar, Stefan, Dominguez Pardo, Juan, Killian, J Antoinette, Membrane Biochemistry and Biophysics, Dörr, Jonas M, Schäfer, Marre, Koorengevel, Martijn C, van Walree, Cornelis A   +8 more
core   +2 more sources