Results 181 to 190 of about 29,208 (221)

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Unraveling the role of membrane microdomains during microbial infections. [PDF]

Cell Biol Toxicol, 2017
Bagam P, Singh DP, Inda ME, Batra S.
europepmc   +1 more source

The endoplasmic reticulum in mitochondrial protein targeting: A neuronal perspective on organelle crosstalk

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Neurons depend on tightly regulated spatial proteostasis to maintain function across their extended morphology. The endoplasmic reticulum (ER), traditionally known for its function in protein synthesis, folding, and trafficking, has long been recognized as a central platform for directing proteins to organelles of the secretory and endocytic ...
J. Tabitha Hees, Angelika B. Harbauer
wiley   +1 more source

Insights into the roles of RALF peptides and CrRLK1L receptors in fruit ripening

The Plant Journal, Volume 125, Issue 5, March 2026.
SUMMARY The rapid alkalinization factor (RALF) family of small signaling peptides regulates diverse physiological and developmental processes in plants. RALF peptides influence cell wall remodeling and hormonal homeostasis through interactions with CrRLK1L malectin‐like receptor kinases and leucine‐rich repeat extensin (LRX) proteins anchored to the ...
José A. Montano, Sara Posé, José A. Mercado, Verónica G. Doblas   +3 more
wiley   +1 more source

Matrix Rigidity-Dependent Regulation of Ca²⁺ at Plasma Membrane Microdomains by FAK Visualized by Fluorescence Resonance Energy Transfer. [PDF]

Adv Sci (Weinh), 2019
Kim TJ, Lei L, Seong J, Suh JS, Jang YK, Jung SH, Sun J, Kim DH, Wang Y.   +8 more
europepmc   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

Optimal neuromuscular performance requires motor neuron phosphagen kinases

The Journal of Physiology, Volume 604, Issue 5, Page 2027-2059, 1 March 2026.
Abstract figure legend Motor neuron (MN) terminals in fruit flies, mice and humans contain phosphagen kinases, a key enzyme in their energy storage and buffering system. Here we knocked down the primary phosphagen kinase in fruit fly larvae (arginine kinase 1 (ArgK1)) but were surprised to find that MN endurance was unaffected.
Karlis A. Justs, Danielle V. Latner (nee Riboul), Carlos D. Oliva, Yosuf Arab, Gabriel G. Bonassi, Olena Mahneva, Sarah Crill, Sergio Sempertegui, Paul A. Kirchman, Yaouen Fily, Gregory T. Macleod   +10 more
wiley   +1 more source

oxLDL and eLDL Induced Membrane Microdomains in Human Macrophages. [PDF]

PLoS One, 2016
Wallner S, Grandl M, Liebisch G, Peer M, Orsó E, Sigrüner A, Sobota A, Schmitz G.   +7 more
europepmc   +1 more source