Two hit mitochondrial-driven model of synapse loss in neurodegeneration
Neurobiology of Disease, 2021 In healthy neurons, a mitochondrial membrane potential gradient exists whereby membrane potential is highest in the soma and decreases with distance from the nucleus.
Sergei V. Baranov +3 more
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How DASPMI reveals mitochondrial membrane potential : fluorescence decay kinetics and steady-state anisotropy in living cells [PDF]
, 2008 Spectroscopic responses of the potentiometric probe 2-(4-(dimethylamino)styryl)-1-methylpyridinium iodide (DASPMI) were investigated in living cells by means of a time- and space-correlated single photon counting technique.
Ramadass, Radhan, Bereiter-Hahn, Jürgen
core +1 more source
Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation
Frontiers in Chemistry, 2020 There is considerable interest in developing drugs and probes targeted to mitochondria in order to understand and treat the many pathologies associated with mitochondrial dysfunction.
Laura Pala +10 more
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Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism [PDF]
, 2018 Environmental stressors like ethanol (EtOH) commonly target mitochondria to influence the cell’s fate. Recent literature supports that chronic EtOH exposure suppresses mitochondrial dynamics, central to quality control, and sensitizes mitochondrial ...
Hajnóczky, György +4 more
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Flow Cytometric Detection of Mitochondrial Membrane Potential
Bio-Protocol, 2013 Mitochondrial membrane potential (Δψm) is an important parameter of mitochondrial function and an indicator of cell health. Depletion of Δψm suggests the loss of mitochondrial membrane integrity reflecting the initiation of the proapoptotic signal ...
Hsin-Yi Chang +5 more
doaj +1 more source
Strategies for maximizing ATP supply in the microsporidian Encephalitozoon cuniculi: direct binding of mitochondria to the parasitophorous vacuole and clustering of the mitochondrial porin VDAC [PDF]
, 2013 Microsporidia are obligate intracellular parasites with extremely reduced genomes and a dependence on host-derived ATP. The microsporidium Encephalitozoon cuniculi proliferates within a membranous vacuole and we investigated how the ATP supply is ...
Bhella, David +3 more
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Platelet mitochondrial membrane potential in Parkinson's disease [PDF]
Annals of Clinical and Translational Neurology, 2014 AbstractObjectiveMitochondrial dysfunction is a hallmark of idiopathic Parkinson's disease (IPD), which has been reported not to be restricted to striatal neurons. However, studies that analyzed mitochondrial function at the level of selected enzymatic activities in peripheral tissues have produced conflicting data. We considered the electron transport
Paul M. A. Antony +10 more
openaire +3 more sources
Decreased Mitochondrial Membrane Potential Activates the Mitochondrial Unfolded Protein Response
microPublication biology, 2021 Mitochondria are organelles that make ATP by generating a proton gradient across the inner membrane through the action of the electron transport chain (ETC). The gradient is composed of a membrane potential (Δψm) and a concentration gradient (ΔpH). In addition to energy production, mitochondria are recognized as signaling organelles (Chandel 2015), and
Berry, Brandon J. +2 more
openaire +2 more sources
Ca ion transport in smooth muscle mitochondria [PDF]
The Ukrainian Biochemical Journal, 2014 Review focuses on the analysis of literature data and own results concerning properties of mitochondria Са2+ transporting systems and their regulation.
L. G. Babich +2 more
doaj +1 more source
Early steps in mitochondrial protein import [PDF]
, 1990 The process of insertion of precursor proteins into mitochondrial membranes was investigated using a hybrid protein (pSc1-c) that contains dual targeting information and, at the same time, membrane insertion activity.
Neupert, Walter +2 more
core +1 more source