Results 41 to 50 of about 704,164 (306)

In vivo quantification of mitochondrial membrane potential

Nature, 2020
Momcilovic et al1 report mitochondrial metabolism differences amongst various mouse lung cancer subtypes, as measured by positron emission tomography (PET) and a voltage-sensitive tracer. They describe their experiments as measurements of mitochondrial membrane potential, ΔΨm, and suggest that they might be used as a non-invasive biomarker to guide the
Nathaniel M. Alpert, Matthieu Pelletier-Galarneau, Yoann Petibon, Marc D. Normandin, Georges El Fakhri   +4 more
openaire   +4 more sources

Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms

eLife
Mitochondrial membrane potential directly powers many critical functions of mitochondria, including ATP production, mitochondrial protein import, and metabolite transport.
Yeyun Ouyang, Mi-Young Jeong, Corey N Cunningham, Jordan A Berg, Ashish G Toshniwal, Casey E Hughes, Kristina Seiler, Jonathan G Van Vranken, Ahmad A Cluntun, Geanette Lam, Jacob M Winter, Emel Akdogan, Katja K Dove, Sara M Nowinski, Matthew West, Greg Odorizzi, Steven P Gygi, Cory D Dunn, Dennis R Winge, Jared Rutter   +19 more
doaj   +1 more source

Hormone deprivation alters mitochondrial function and lipid profile in the hippocampus [PDF]

, 2017
Mitochondrial dysfunction is a common hallmark in aging. In the female, reproductive senescence is characterized by loss of ovarian hormones, many of whose neuroprotective effects converge upon mitochondria.
Alvarez, Silvia, Astiz, Mariana, Imsen, Mercedes, Magnani, Natalia Daniela, Merino, Florencia, Reines, Analia Gabriela, Seilicovich, Adriana, Zarate, Sandra Cristina   +7 more
core   +2 more sources

Mitotracker probes and mitochondrial membrane potential [PDF]

Shock, 2013
In the recent article by Lin et al. (1), the authors demonstrate protective effects of splenic infusion of isolated mitochondria against hepatic ischemia/reperfusion injury in a rat model. One of their conclusions is that the isolated mitochondria from donor animals maintained an intact membrane potential in the livers of recipient animals even at 4 ...
Han-Chen Lin, I-Rue Lai
openaire   +2 more sources

Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism

Frontiers in Physiology, 2018
Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single ...
Alexis R. Díaz-Vegas, Alex Cordova, Denisse Valladares, Denisse Valladares, Paola Llanos, Paola Llanos, Cecilia Hidalgo, Gaia Gherardi, Diego De Stefani, Cristina Mammucari, Rosario Rizzuto, Ariel Contreras-Ferrat, Enrique Jaimovich   +12 more
doaj   +1 more source

Modulation of myometrium mitochondrial membrane potential by calmodulin antagonists [PDF]

The Ukrainian Biochemical Journal, 2014
Influence of calmodulin antagonists on mitochondrial membrane potential was investigated using­ a flow cytometry method, confocal microscopy and fluorescent potential-sensitive probes TMRM and MTG.
S. G. Shlykov, L. G. Babich, M. E. Yevtushenko, S. O. Karakhim, S. O. Kosterin   +4 more
doaj   +1 more source

Involvement of Mitochondrial Dysfunction in the Inflammatory Response in Human Mesothelial Cells from Peritoneal Dialysis Effluent

Antioxidants, 2022
Recent studies have related mitochondrial impairment with peritoneal membrane damage during peritoneal dialysis (PD) therapy. Here, we assessed the involvement of mitochondrial dysfunction in the inflammatory response in human mesothelial cells, a ...
Olalla Ramil-Gómez, Mirian López-Pardo, Jennifer Adriana Fernández-Rodríguez, Ana Rodríguez-Carmona, Teresa Pérez-López, Carlos Vaamonde-García, Miguel Pérez-Fontán, María José López-Armada   +7 more
doaj   +1 more source

Adenine Nucleotide Translocase 1 Expression is Coupled to the HSP27-Mediated TLR4 Signaling in Cardiomyocytes [PDF]

, 2019
The cardiac-specific overexpression of the adenine nucleotide translocase 1 (ANT1) has cardioprotective effects in various experimental heart disease models.
Dörner, Andrea, Hammer, Elke, Heger, Jacqueline, Landmesser, Ulf, Rauch, Ursula, Schultheiss, Heinz-Peter, Winter, Julia   +6 more
core   +2 more sources

Imaging mitochondrial membrane potentials

Biophysical Journal, 1993
process remain to be elucidated. The elusiveness of this goal can be attributed, at least in part, to the absence of structural information about the mitochondrion itself at several levels of complexity. It is obvious, for example, that obtaining atomic structures of the respiratory chain protein complexes by x-ray or electron crystallography would ...
openaire   +2 more sources

Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects

Neurobiology of Disease, 2011
Mutations in PTEN-induced putative kinase 1 (PINK1) cause a recessive form of Parkinson's disease (PD). PINK1 is associated with mitochondrial quality control and its partial knock-down induces mitochondrial dysfunction including decreased membrane ...
Taku Amo, Shigeto Sato, Shinji Saiki, Alexander M. Wolf, Masaaki Toyomizu, Clement A. Gautier, Jie Shen, Shigeo Ohta, Nobutaka Hattori   +8 more
doaj   +1 more source