Results 51 to 60 of about 704,164 (306)

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons [PDF]

, 2017
Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential ...
Abramov, Andrey Y. Abramov, Angelova, Bartolome, Bobba, Brand, Brown, Charles Arber, Ding, Edri, Elisavet Preza, Eva Carro, Fernando Bartolome, Ganote, Henry Houlden, Imamura, Johnson, Kokoszka, Krauss, Ludtmann, Macarena de Vicente, Marthe H.R. Ludtmann, Meyer, Muqit, Nalbandian, Nalbandian, Nalbandian, Okita, Papkovskaia, Plun-Favreau, Schirris, Selina Wray, Shi, Shi, Sonia Gandhi, Sposito, Vallier, Vieira, Weihl, Weinbach, Weydt, Wray, Yin, Zhivotovsky   +43 more
core   +2 more sources

Calcineurin, Mitochondrial Membrane Potential, and Cardiomyocyte Apoptosis [PDF]

Circulation Research, 2001
Mitochondria comprise ≈30% of the total intracellular volume within a mammalian cardiomyocyte.1 2 Not surprisingly, subtle alterations in mitochondrial function or membrane potential can have a dramatic influence on cardiomyocyte energy production and, ultimately, the health of an individual cell.
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Analysis of the Mitochondrial Membrane Potential Using the Cationic JC-1 Dye as a Sensitive Fluorescent Probe

Bio-Protocol, 2019
In recent years, fluorescent dyes have been frequently used for monitoring mitochondrial membrane potential to evaluate mitochondrial viability and function.
Farzane Sivandzade, Aditya Bhalerao, Luca Cucullo   +2 more
doaj   +1 more source

The role of DJ-1 in enhancing mitochondrial quality control [PDF]

, 2013
Thesis (M.A.)--Boston UniversityDJ-1 is a cytosolic sensor for oxidative damage which acts on the Mitochondria. It works to curb the negative effects of high membrane potential in mitochondria, but the mechanism of action is still uncertain.
Lingiah, Krishna Anand
core   +1 more source

Cytoprotective effects of melatonin against amitriptyline-induced toxicity in isolated rat hepatocytes [PDF]

, 2015
Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are
Dastmalchi, S., Eghbal, M.A., Sattari, M.R., Taziki, S.   +3 more
core   +1 more source

Mitochondrial membrane potential and aging

Aging Cell, 2003
SummaryThe mitochondrial membrane potential (or protonmotive force) is the central bioenergetic parameter that controls respiratory rate, ATP synthesis and the generation of reactive oxygen species, and is itself controlled by electron transport and proton leaks.
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The carboxyl-terminal two-thirds of the ADP/ATP carrier polypeptide contains sufficient information to direct translocation into mitochondria [PDF]

, 1987
The precursor of the mitochondrial inner membrane protein ADP/ATP carrier is cytoplasmically synthesized without an amino-terminal peptide extension. We constructed a truncated precursor lacking the 103 amino acids from the amino terminus (about a third ...
Hoeben, Peter, Neupert, Walter, Pfanner, Nikolaus, Tropschug, Maximilian   +3 more
core  

Requirement of a Membrane Potential for the Posttranslational Transfer of Proteins into Mitochondsria [PDF]

, 1982
Posttranslational transfer of most precursor proteins into mitochondria is dependent on energization of the mitochondria. Experiments were carried out to determine whether the membrane potential or the intramitochondrial ATP is the immediate energy ...
Conboy J. G., Cote C., Daniels C. J., Data T., Date T., Enequist H. G., Graven S. N., Hallermayer G., Harmey M. A., Harmey M. A., Heldt H. W., Heytler P. G., Josefson L. G., Kekssler S. W., Korb H., Kovac L., Laemmli U. K., Lambowitz A. M., Lambowitz A. M., Maccechini M.-L., Matsuura S., Michel R., Mori M., Mori M., Nelson N., Passarella S., Pelham H. R. B., Raymond Y., Sebald W., Sebald W., Stigall D. L., Subik J., Tzagoloff A., Vignais P. V., Weiss H., Zimmermann R., Zimmermann R., Zimmermann R.   +37 more
core   +1 more source