Results 141 to 150 of about 14,870,238 (380)

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Cellular Membrane Potentials and Contractility of Normal Rat Atrium and the Effects of Temperature, Tension and Stimulus Frequency [PDF]

, 1955
Philip B. Hollander, J. Webb
openalex   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Membrane potentials of cancer cells.pdf

, 2017
We discuss why the membrane potentials of cancer cells are often smaller than those of healthy cells, and why the stresses associated with reduced membrane potentials might not automatically cause destruction of cells by apoptosis.The fact that cytochrome c appears as a key intermediary both in cellular respiration and in apoptosis suggests that damage
openaire   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Membrane Instantons and de Sitter Vacua

, 2005
We investigate membrane instanton effects in type IIA strings compactified on rigid Calabi-Yau manifolds. These effects contribute to the low-energy effective action of the universal hypermultiplet.
A. Saltman, B. de Wit, B. de Wit, C. Escoda, C. Lebrun, C.P. Burgess, D. Joyce, E. Bergshoeff ., E. Bergshoeff ., E. Silverstein, F. Denef, F. Denef, Frank Saueressig, H. Lin, I. Antoniadis, J.A. Harvey, J.J. Blanco-Pillado ., J.P. Gauntlett, K. Behrndt, K.P. Tod, L. Jarv, M. Aganagic, M. Bodner, M. Gutperle, Marijn Davidse, N. Dorey, N. Seiberg, P. Berglund, P. Fre, P.S. Aspinwall, P.S. Aspinwall, R. Kallosh, R.S. Ward, S. Ferrara, S. Kachru, S. Kachru ., S.Y. Alexandrov, S.Y. Alexandrov, Stefan Vandoren, T. Mohaupt, U. Theis, U. Theis, Ulrich Theis, V. Balasubramanian, V. Balasubramanian, V. Cortes, V. Cortes   +46 more
core   +1 more source

Effects of Adenine Nucleotides on the Contractility and Membrane Potentials of Rat Atrium [PDF]

, 1957
PHILIPS B. HOLLANDER, LEYDEN WEBB
openalex   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Deficiency of dltD contributes to increased autolysis in Streptococcus mutans

Journal of Oral Microbiology
Streptococcus mutans (S. mutans) is one of the major etiological agents of dental caries. Interfering with the expression of genes associated with cariogenicity of S. mutans is an effective ecological approach for caries prevention.
Jingyun Du, Shan Huang, Yijun Li, Minjing Wu, Shuai Chen, Ling Zhan, Xiaojing Huang   +6 more
doaj   +1 more source

Distinct steps in the import of ADP/ATP carrier into mitochondria [PDF]

, 1987
Transport of the precursor to the ADP/ATP carrier from the cytosol into the mitochondrial inner membrane was resolved into several consecutive steps. The precursor protein was trapped at distinct stages of the import pathway and subsequently chased to ...
Neupert, Walter, Pfanner, Nikolaus
core