Results 131 to 140 of about 11,716,491 (307)

Is There No Need to Consider the Influence of Ion Adsorption and the Hofmeister Effect for the Precise Evaluation of Membrane Potential?

Biophysica
Within the field of physiology, it is widely recognized that the constant flow of mobile ions across the plasma membrane generates membrane potential in living cells. This understanding is a part of the membrane theory. Despite this, membrane theory does
Hirohisa Tamagawa, Iori Kojima, Anh Lan Duong, Bernard Delalande   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Membrane biofouling and scaling in forward osmosis membrane bioreactor

, 2012
The forward osmosis membrane bioreactor (FOMBR) has received much attention recently. Due to the high rejection nature of FO membranes, the biomass, dissolved organic and inorganic compounds retained in the bioreactor could cause membrane fouling by ...
Fane, Anthony Gordon, Lay, Winson Chee Loong, Tang, C, Wang, Rong, Chou, Shuren, Tang, Chuyang Y., Wang, R, Fane, AG, Loong, WLC, Zhang, J, Chou, S, Zhang, Jinsong   +11 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The potential roles of granular activated carbon in anaerobic fluidized membrane bioreactors : effect on membrane fouling and membrane integrity

, 2014
This study examined the behavior of granular activated carbon (GAC) in a hybrid GAC-microfiltration process, which was used to simulate an anaerobic fluidized membrane bioreactor.
Fane, Anthony Gordon, Wu, Bing, Wong, Philip Chuen Yung   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mechanisms regulating the acyl chain composition of membrane lipids in S. cerevisiae [PDF]

, 2011
The goal of the research described in this thesis was to identify the genes/enzymes involved in acyl chain remodeling of the major membrane lipid phosphatidylcholine (PC) in the model eukaryote S. cerevisiae. A database search yielded 75 candidates with (
De Smet, C.H., Sub Membrane Enzymology begr. 01-06-12, Biochemistry of membranes, Membrane Enzymology   +3 more
core   +1 more source

Growth phase-specific induction of a viable but nonculturable (VBNC) state in Listeria innocua in response to a green food sanitizer

Microbiology Spectrum
Sustainable food sanitation and preservation technologies are highly needed to meet the increasing demand for healthy and safe food. In this work, we investigated the effects of a recently developed antimicrobial triple formulation (TF) comprised of a ...
Esther W. Mwangi, Moshe Shemesh, Victor Rodov   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source