Results 81 to 90 of about 14,870,238 (380)

The role of DJ-1 in enhancing mitochondrial quality control [PDF]

, 2013
Thesis (M.A.)--Boston UniversityDJ-1 is a cytosolic sensor for oxidative damage which acts on the Mitochondria. It works to curb the negative effects of high membrane potential in mitochondria, but the mechanism of action is still uncertain.
Lingiah, Krishna Anand
core   +1 more source

Electrostatics of ions inside the nanopores and trans-membrane channels

, 2006
A model of a finite cylindrical ion channel through a phospholipid membrane of width $L$ separating two electrolyte reservoirs is studied. Analytical solution of the Poisson equation is obtained for an arbitrary distribution of ions inside the trans ...
Corry B., Doyle D. A., Hille B., Jackson J. D., Jordan P. C., Jordan P. C., Kuyucak S., Levin Y., Levitt D. G., Moy G., Smythe W. R., Teber S., Tieleman D. P., Y Levin   +13 more
core   +1 more source

How Well Can You Tailor the Charge of Lipid Vesicles? [PDF]

, 2019
Knowledge and control of surface charge or potential is important for tailoring colloidal interactions. In this work, we compare widely used zeta potential (ζ) measurements of charged lipid vesicle surface potential to direct measurements using the ...
Docto, D, Gilbile, D, Kingi, DT, Kuhl, TL, Kurniawan, J, Monahan, D, Tang, A   +6 more
core   +2 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

MODULATION OF DEFENSIVE REFLEX CONDITIONING IN SNAILS BY SEROTONIN

Frontiers in Behavioral Neuroscience, 2015
We studied the role of serotonin in the mechanisms of learning in terrestrial snails. To produce a serotonin deficit, the neurotoxic analogues of serotonin, 5,6- or 5,7-dihydroxytryptamine (5,6/5,7-DHT) were used.
Vyatcheslav V Andrianov, Vyatcheslav V Andrianov, Tatiana Kh Bogodvid, Tatiana Kh Bogodvid, Irina B Deryabina, Aleksandra N Golovchenko, Lyudmila N Muranova, Roza R Tagirova, Alia Kh Vinarskaya, Khalil L Gainutdinov, Khalil L Gainutdinov   +10 more
doaj   +1 more source

Real-time monitoring of proton exchange membrane fuel cell stack failure [PDF]

, 2016
Uneven pressure drops in a 75-cell 9.5-kWe proton exchange membrane fuel cell stack with a U-shaped flow configuration have been shown to cause localised flooding.
Brandon, NP, De Benedetti, L, Marquis, AJ, Offer, GJ, Parkes, MP, Wu, B   +5 more
core   +2 more sources

Imaging mitochondrial membrane potentials

Biophysical Journal, 1993
process remain to be elucidated. The elusiveness of this goal can be attributed, at least in part, to the absence of structural information about the mitochondrion itself at several levels of complexity. It is obvious, for example, that obtaining atomic structures of the respiratory chain protein complexes by x-ray or electron crystallography would ...
openaire   +3 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

De Novo Emergence of Peptides That Confer Antibiotic Resistance

mBio, 2019
The origin of novel genes and beneficial functions is of fundamental interest in evolutionary biology. New genes can originate from different mechanisms, including horizontal gene transfer, duplication-divergence, and de novo from noncoding DNA sequences.
Michael Knopp, Jonina S. Gudmundsdottir, Tobias Nilsson, Finja König, Omar Warsi, Fredrika Rajer, Pia Ädelroth, Dan I. Andersson   +7 more
doaj   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source