Results 71 to 80 of about 2,440,422 (308)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Development of highly-efficient ZIF-8@PDMS/PVDF nanofibrous composite membrane for phenol removal in aqueous-aqueous membrane extractive process

, 2018
A highly-efficient zeolitic imidazolate framework-8 (ZIF-8) embedded polydimethylsiloxane (PDMS) mixed matrix membrane (MMM) supported by a polyvinylidene fluoride (PVDF) nanofibrous substrate was developed for phenol removal in an aqueous-aqueous ...
Tan, Choon-Hong, Wang, Rong, Jin, Meng-Yi, Lin, Yuqing, Liao, Yuan   +4 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Analyzing external and internal membrane fouling by oil emulsions via 3D optical coherence tomography

, 2017
Membrane-based filtration is an emerging technique for processing oily wastewater. Improving the efficiency of oil-water separation via membranes entails novel techniques for studying the complex interactions between the oil droplets and membrane ...
Qi Han, Weiyi Li, Fane, Anthony G., Anthony G. Fane, Han, Qi, Li, Weiyi, Thien An Trinh, Xin Liu, Liu, Xin, Trinh, Thien An, Jia Wei Chew, Chew, Jia Wei   +11 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Microbe-Derived Indole Metabolite Demonstrates Potent Multidrug Efflux Pump Inhibition in Staphylococcus aureus

Frontiers in Microbiology, 2019
Efflux pumps are always at the forefront of bacterial multidrug resistance and account for the failure of antibiotics. The present study explored the potential of 2-(2-Aminophenyl) indole (RP2), an efflux pump inhibitor (EPI) isolated from the soil ...
Rushikesh Tambat, Manoj Jangra, Nisha Mahey, Nishtha Chandal, Manpreet Kaur, Surbhi Chaudhary, Dipesh Kumar Verma, Krishan Gopal Thakur, Manoj Raje, Sanjay Jachak, Neeraj Khatri, Hemraj Nandanwar   +11 more
doaj   +1 more source

Monitoring membrane biofouling via ultrasonic time-domain reflectometry enhanced by silica dosing

, 2012
Detecting biofouling noninvasively in real-time has been a long-standing challenge in membrane processes. Ultrasonic Time Domain Reflectometry (UTDR) offers the potential to address this challenge when used in a ‘canary cell’ that samples a slip stream ...
Fane, Anthony Gordon, Sim, S. T. V., Chong, T. H., Krantz, William B., Suwarno, S. R.   +4 more
core   +1 more source

Calcium phosphate scaling in osmotically driven membrane processes: limiting flux behavior and its implications for scaling mitigation

, 2021
Calcium phosphate scaling, a typical inorganic scaling, has been identified as a challenging issue in the operation of osmotically driven membrane processes (ODMPs) especially in pressure-retarded osmosis (PRO) mode where membrane porous substrate faces ...
Wiley, Dianne E., She, Qianhong, Liu, Zongwen, Fei, Jingyuan, Lyu, You, Zhong, Xia   +5 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Manipulation of isolated brain nerve terminals by an external magnetic field using D-mannose-coated γ-Fe2O3 nano-sized particles and assessment of their effects on glutamate transport

Beilstein Journal of Nanotechnology, 2014
The manipulation of brain nerve terminals by an external magnetic field promises breakthroughs in nano-neurotechnology. D-Mannose-coated superparamagnetic nanoparticles were synthesized by coprecipitation of Fe(II) and Fe(III) salts followed by oxidation
Tatiana Borisova, Natalia Krisanova, Arsenii Borуsov, Roman Sivko, Ludmila Ostapchenko, Michal Babic, Daniel Horak   +6 more
doaj   +1 more source