Results 81 to 90 of about 11,716,491 (307)

Transport and sorting of membrane lipids [PDF]

, 1993
The lipid composition of cellular membranes may seem unnecessarily complex. However, the lipid composition of each membrane is carefully regulated by local metabolism and specificity in transport, marking the functional significance for the cell.
van Meer, G., Universiteit Utrecht, Dep Scheikunde, Membrane Enzymology   +3 more
core   +1 more source

Microbe-Derived Indole Metabolite Demonstrates Potent Multidrug Efflux Pump Inhibition in Staphylococcus aureus

Frontiers in Microbiology, 2019
Efflux pumps are always at the forefront of bacterial multidrug resistance and account for the failure of antibiotics. The present study explored the potential of 2-(2-Aminophenyl) indole (RP2), an efflux pump inhibitor (EPI) isolated from the soil ...
Rushikesh Tambat, Manoj Jangra, Nisha Mahey, Nishtha Chandal, Manpreet Kaur, Surbhi Chaudhary, Dipesh Kumar Verma, Krishan Gopal Thakur, Manoj Raje, Sanjay Jachak, Neeraj Khatri, Hemraj Nandanwar   +11 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Manipulation of isolated brain nerve terminals by an external magnetic field using D-mannose-coated γ-Fe2O3 nano-sized particles and assessment of their effects on glutamate transport

Beilstein Journal of Nanotechnology, 2014
The manipulation of brain nerve terminals by an external magnetic field promises breakthroughs in nano-neurotechnology. D-Mannose-coated superparamagnetic nanoparticles were synthesized by coprecipitation of Fe(II) and Fe(III) salts followed by oxidation
Tatiana Borisova, Natalia Krisanova, Arsenii Borуsov, Roman Sivko, Ludmila Ostapchenko, Michal Babic, Daniel Horak   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effect of humic-acid fouling on membrane distillation

, 2016
Membrane distillation (MD) can concentrate non-volatile solutes or remove volatiles and dissolved gases from an aqueous feed. A microporous hydrophobic membrane provides a barrier between the hot feed and cold distillate.
Tan, Yong Zen, Krantz, William B., Chew, Jia Wei   +2 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Structural stability and mass transfer properties of pressure retarded osmosis (PRO) membrane under high operating pressures

, 2015
The fabrication of new membrane that is able to produce stable high power density is essential for the development of pressure retarded osmosis (PRO) technology.
Li, Ye, Qi, S, Tang, C, Li, Y, Wang, Rong, Wang, R, Tang, Chuyang, Qi, Saren   +7 more
core   +1 more source

Six principles of visual cortical dynamics

Frontiers in Systems Neuroscience, 2010
A fundamental goal in vision science is to determine how many neurons in how many areas are required to compute a coherent interpretation of the visual scene.
Per E Roland
doaj   +1 more source