Results 141 to 150 of about 12,112,951 (393)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Increased inhibitory input to CA1 pyramidal cells alters hippocampal gamma frequency oscillations in the MK-801 model of acute psychosis

Neurobiology of Disease, 2007
The phencyclidine compound MK-801 can induce psychosis with symptoms which closely resemble those observed in an acute schizophrenic episode. Here we used an in vitro model of psychosis after systemic administration of MK-801.
Colin Kehrer, Tamar Dugladze, Nino Maziashvili, Anna Wójtowicz, Dietmar Schmitz, Uwe Heinemann, Tengis Gloveli   +6 more
doaj  

Reversibly Migratable Fluorescent Probe for Precise and Dynamic Evaluation of Cell Mitochondrial Membrane Potentials. [PDF]

Biosensors (Basel), 2022
Song G, He H, Chen W, Lv Y, Chu PK, Wang H, Li P.   +6 more
europepmc   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Monitoring of compound resting membrane potentials of cell cultures with ratiometric genetically encoded voltage indicators. [PDF]

Commun Biol, 2021
Rühl P, Langner JM, Reidel J, Schönherr R, Hoshi T, Heinemann SH.   +5 more
europepmc   +1 more source

Effect of Indole-3-acetic Acid on Membrane Potentials of Oat Coleoptile Cells.

Plant Physiology, 1970
This paper reports an effect of indole-3-acetic acid on cell membrane potentials. Solutions with increasing IAA concentrations (from 109 to 10-7 M) make membrane potentials of coleoptile cells more negative.
B. Etherton
semanticscholar   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Kv11 (ether-à-go-go-related gene) voltage-dependent K⁺ channels promote resonance and oscillation of subthreshold membrane potentials. [PDF]

J Physiol, 2021
Matsuoka T, Yamasaki M, Abe M, Matsuda Y, Morino H, Kawakami H, Sakimura K, Watanabe M, Hashimoto K.   +8 more
europepmc   +1 more source

Effects of Adenine Nucleotides on the Contractility and Membrane Potentials of Rat Atrium [PDF]

, 1957
PHILIPS B. HOLLANDER, LEYDEN WEBB
openalex   +1 more source

Cellular energy metabolism, trans-plasma and trans-mitochondrial membrane potentials, and pH gradients in mouse neuroblastoma.

Proceedings of the National Academy of Sciences of the United States of America, 1979
A method for quantitative evaluation of transmembrane electrical potential and pH gradients across a subcellular compartment in an intact cell is presented.
C. Deutsch, M. Erecínska, R. Werrlein, I. Silver   +3 more
semanticscholar   +1 more source