Results 61 to 70 of about 2,314,591 (317)

Protein kinase FAM20C—when subcellular localization matters

FEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Expression and Purification of the Human Voltage-Gated Proton Channel (hHv1)

Bio-Protocol
The voltage-gated proton channel (Hv1) is a membrane protein that dissipates acute cell proton accumulations. To understand the molecular mechanisms explaining Hv1 function, methods for purifying the protein are needed. Previously, methods were developed
Emerson Carmona, D. Marien Cortes, Luis Cuello   +2 more
doaj   +1 more source

Rotational Diffusion of Membrane Proteins: Characterization of Protein-Protein Interactions in Membranes [PDF]

Biophysical Journal, 2012
It has long been appreciated that the rotational diffusion coefficient (Dr) and hence the rotational correlation time (τr) of a transmembrane protein about its membrane normal axis is predicted to be highly sensitive to its cylindrical radius (e.g., Saffman and Delbruck (1)). Due to the highly viscous nature of a cellular membrane or a membrane bilayer,
openaire   +3 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis

Scientific Reports, 2017
VEGF-C is essential for lymphangiogenesis during development and tumor progression. VEGFR-3 is the well-known cognate receptor of VEGF-C to regulate lymphatic migration and proliferation, but the receptor of VEGF-C in regulating lymphatic sprouting, the ...
Huiwen Yan, Chunxia Zhang, Zhaoqing Wang, Tao Tu, Hongxia Duan, Yongting Luo, Jing Feng, Feng Liu, Xiyun Yan   +8 more
doaj   +1 more source

Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2

Cell Reports, 2018
Summary: Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms ...
Wang Zheng, Ruiqi Cai, Laura Hofmann, Vasyl Nesin, Qiaolin Hu, Wentong Long, Mohammad Fatehi, Xiong Liu, Shaimaa Hussein, Tim Kong, Jingru Li, Peter E. Light, Jingfeng Tang, Veit Flockerzi, Leonidas Tsiokas, Xing-Zhen Chen   +15 more
doaj   +1 more source

Autoinhibition of TRPV6 Channel and Regulation by PIP2

iScience, 2020
Summary: Transient receptor potential vanilloid 6 (TRPV6), a calcium-selective channel possessing six transmembrane domains (S1-S6) and intracellular N and C termini, plays crucial roles in calcium absorption in epithelia and bone and is involved in ...
Ruiqi Cai, Xiong Liu, Rui Zhang, Laura Hofmann, Wang Zheng, Md Ruhul Amin, Lingyun Wang, Qiaolin Hu, Ji-Bin Peng, Marek Michalak, Veit Flockerzi, Declan W. Ali, Xing-Zhen Chen, Jingfeng Tang   +13 more
doaj   +1 more source

Basement membrane proteins

Kidney International, 1992
Basement membranes are heterogeneous, highly specialized, electron-dense structures constructed from components of extracellular matrix proteins 20 to 200nm in width. They provide anchorage for adjacent cells as well as stimuli for cell differentiation, cell migration, and cell phenotype.
openaire   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source