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The rapid developments of membrane protein structure biology over the last two decades
Membrane protein research has flourished in the past 20 years. Exciting technological innovations in structural biology, including cryoEM single-particle analysis and AI-based protein structure prediction, such as AlphaFold 2, have largely revolutionized
Lan Guan
doaj +1 more source
Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding [PDF]
The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing ...
Adair+63 more
core +3 more sources
Structures of membrane proteins [PDF]
AbstractIn reviewing the structures of membrane proteins determined up to the end of 2009, we present in words and pictures the most informative examples from each family. We group the structures together according to their function and architecture to provide an overview of the major principles and variations on the most common themes.
Kutti R. Vinothkumar, Richard Henderson
openaire +2 more sources
Conformational dynamics of the human serotonin transporter during substrate and drug binding
The serotonin transporter (SERT) is responsible for re-uptake of serotonin into the presynaptic neuron and plays a key role in synaptic transmission. Here, the authors use hydrogen-deuterium exchange mass spectrometry to probe the conformational dynamics
Ingvar R. Möller+6 more
doaj +1 more source
Structural insight into the mechanism of energy transfer in cyanobacterial phycobilisomes
The major light-harvesting systems for photosynthesis in cyanobacteria and red algae are phycobilisomes (PBS). Here, the authors present the cryo-EM structures of two cyanobacterial PBS from Anabaena 7120 and Synechococcus 7002 and discuss their energy ...
Lvqin Zheng+7 more
doaj +1 more source
An Integrated Framework Advancing Membrane Protein Modeling and Design
Membrane proteins are critical functional molecules in the human body, constituting more than 30% of open reading frames in the human genome. Unfortunately, a myriad of difficulties in overexpression and reconstitution into membrane mimetics severely ...
Rebecca F. Alford+6 more
semanticscholar +1 more source
Diffusing proteins on a fluctuating membrane: Analytical theory and simulations
Using analytical calculations and computer simulations we consider both the lateral diffusion of a membrane protein and the fluctuation spectrum of the membrane in which the protein is embedded.
B. Alberts+5 more
core +1 more source
Alternative 3'UTRs act as scaffolds to regulate membrane protein localization
About half of human genes use alternative cleavage and polyadenylation (ApA) to generate messenger RNA transcripts that differ in the length of their 3′ untranslated regions (3′ UTRs) while producing the same protein.
Binyamin D. Berkovits, C. Mayr
semanticscholar +1 more source
Structural Biology and Structure–Function Relationships of Membrane Proteins
To understand the biological complexity of life, one needs to investigate how biomolecules behave and interact with each other at a molecular level [...]
Isabel Moraes, Andrew Quigley
doaj +1 more source
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali+3 more
wiley +1 more source