A non-canonical activation of the host's ESCRT machinery is required for the scission of parasitophorous vacuoles and the replication of Leishmania donovani. [PDF]
PLoS PathogRosero J, Kima PE.
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The actin nucleation promoting factor WASH facilitates clathrin-independent endocytosis of human papillomaviruses. [PDF]
EMBO RepBrinkert P +11 more
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Actin Dynamics Drive Membrane Reorganization and Scission in Clathrin-Independent Endocytosis [PDF]
Cell, 2010 Nascent transport intermediates detach from donor membranes by scission. This process can take place in the absence of dynamin, notably in clathrin-independent endocytosis, by mechanisms that are yet poorly defined. We show here that in cells scission of Shiga toxin-induced tubular endocytic membrane invaginations is preceded by cholesterol-dependent ...
Christophe Lamaze +2 more
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Friction Mediates Scission of Tubular Membranes Scaffolded by BAR Proteins [PDF]
Cell, 2017 Membrane scission is essential for intracellular trafficking. While BAR domain proteins such as endophilin have been reported in dynamin-independent scission of tubular membrane necks, the cutting mechanism has yet to be deciphered. Here, we combine a theoretical model, in vitro, and in vivo experiments revealing how protein scaffolds may cut tubular ...
Anne Kenworthy +2 more
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Structural characterization of an Arf dimer interface: molecular mechanism of Arf‐dependent membrane scission [PDF]
FEBS Letters, 2020 Dimerization of the small GTPase Arf is prerequisite for the scission of COPI-coated transport vesicles. Here, we quantify the monomer/dimer equilibrium of Arf within the membrane and show that after membrane scission, Arf dimers are restricted to donor ...
Rebecca Wade +2 more
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Coupling between Clathrin-Coated-Pit Invagination, Cortactin Recruitment, and Membrane Scission Observed in Live Cells [PDF]
Cell, 2005 SummaryDuring clathrin-mediated endocytosis, membrane scission marks the isolation of a cargo-laden clathrin-coated pit (CCP) from the cell exterior. Here we used live-cell imaging of a pH-sensitive cargo to visualize the formation of clathrin-coated ...
David Ženíšek +2 more
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Membrane budding and scission by the ESCRT machinery: it's all in the neck [PDF]
Nature Reviews Molecular Cell Biology, 2010 The endosomal sorting complexes required for transport (ESCRTs) catalyse one of the most unusual membrane remodelling events in cell biology. ESCRT-I and ESCRT-II direct membrane budding away from the cytosol by stabilizing bud necks without coating the buds and without being consumed in the buds.
James Hurley +2 more
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Coatomer and dimeric ADP ribosylation factor 1 promote distinct steps in membrane scission [PDF]
Journal of Cell Biology, 2011 Formation of coated vesicles requires two striking manipulations of the lipid bilayer. First, membrane curvature is induced to drive bud formation. Second, a scission reaction at the bud neck releases the vesicle.
Paolo Ronchi +2 more
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The ESCRT Membrane Scission Machine
The FASEB Journal, 2020The ESCRT complexes I, II, and III and the AAA+ ATPase VPS4, catalyze reverse‐topology scission from the inner face of membrane necks in HIV budding, multivesicular endosome biogenesis, cytokinesis, and other pathways.
James Hurley +2 more
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