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Membrane trafficking in neurons
Current Biology, 1992Neurons possess an unusually extensive Golgi apparatus and exhibit a variety of active endocytic-like processes. The Golgi apparatus and the endocytic phenomena both contribute, probably in multiple overlapping ways, to the genesis and fate of the membrane systems in axons and terminals.
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Ral: Mediator of membrane trafficking
The International Journal of Biochemistry & Cell Biology, 2006Ral is a multifunctional small GTPase involved in tumorigenesis and in controlling intracellular membrane trafficking. It is mainly activated by factors downstream of Ras, or independently of these factors and operates by protein-protein interactions with an expanding repertoire of partners. RalA is a positive regulator of calcium-evoked exocytosis via
Ellen M, van Dam, Phillip J, Robinson
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1999
Publisher Summary Immunofluorescence microscopy has played a central role in providing information concerning the localization of specific integral membrane proteins. However, immunofluorescence microscopy simply generates a “snapshot” of what is going on and fails to provide direct information concerning the movement of integral membrane proteins in
Sabine Kupzig +2 more
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Publisher Summary Immunofluorescence microscopy has played a central role in providing information concerning the localization of specific integral membrane proteins. However, immunofluorescence microscopy simply generates a “snapshot” of what is going on and fails to provide direct information concerning the movement of integral membrane proteins in
Sabine Kupzig +2 more
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Trafficking of Viral Membrane Proteins
2005Many viruses express membrane proteins. For enveloped viruses in particular, membrane proteins are frequently structural components of the virus that mediate the essential tasks of receptor recognition and membrane fusion. The functional activities of these proteins require that they are sorted correctly in infected cells.
R, Byland, M, Marsh
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Dynamics of Secretory Membrane Trafficking
Annals of the New York Academy of Sciences, 2004Abstract: The study of intracellular membrane trafficking and organelle dynamics has been revolutionized with the advent of GFP technology, which allows individual proteins to be tagged with GFP and monitored in living cells. Using GFP‐based techniques such as selective photobleaching and time‐lapse imaging of different GFP color variants, it is now ...
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Intracellular trafficking of lysosomal membrane proteins
BioEssays, 1996AbstractLysosomes are the site of degradation of obsolete intracellular material during autophagy and of extracellular macromolecules following endocytosis and phagocytosis. The membrane of lysosomes and late endosomes is enriched in highly glycosylated transmembrane proteins of largely unknown function.
W, Hunziker, H J, Geuze
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NHERF: targeting and trafficking membrane proteins
American Journal of Physiology-Renal Physiology, 2001Vectorial ion transport initiated by Na+/H+exchanger isoform 3 (NHE3) mediates the reabsorption of NaCl and NaHCO3in renal proximal tubule cells. NHE3 activity is modulated by numerous physiological stimuli. Biochemical and cellular experiments identified Na+/H+exchanger regulatory factor (NHERF) as a protein cofactor essential for cAMP-mediated ...
S, Shenolikar, E J, Weinman
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Pathways for membrane trafficking during cytokinesis
Trends in Cell Biology, 2004The molecular mechanisms underlying targeted deposition of new membrane at the advancing furrow of a dividing cell have long been intriguing to cell biologists. Three recent studies have made use of Drosophila cellularization to explore current questions in this field.
Laila I, Strickland, David R, Burgess
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Membrane assembly and trafficking: destination Stockholm
Trends in Cell Biology, 2014I can still recall my first glimpse into cell biology. I was 10 years old and the teacher projected a schematic of an animal cell, explaining that cells are factories containing specialized compartments that perform distinct functions. During the lesson she discussed protein transport in the context of the secretory pathway originally discovered by ...
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Plasma Membrane Protein Trafficking
2010The plasma membrane is the interface between the cytosol and the external environment. The proteins that reside and function on the plasma membrane regulate the cellular entrance and exit of bioactive molecules, actuate signaling cascades in response to external stimuli, and potentiate interactions between cells.
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