Results 71 to 80 of about 262,639 (307)

A systematic computational analysis of the endosomal recycling pathway in glioblastoma

Biochemistry and Biophysics Reports
Glioblastoma (GBM) is the most common and aggressive brain cancer in adults. The standard treatment is brutal and has changed little in 20 years, and more than 85% of patients will die within two years of their diagnosis.
Luke J. Joyce, Andrew J. Lindsay
doaj   +1 more source

Network and Evolutionary Analysis Reveals Candidate Genes of Membrane Trafficking Involved in Maize Seed Development and Immune Response

Frontiers in Plant Science, 2022
The plant membrane-trafficking system plays a crucial role in maintaining proper cellular functions and responding to various developmental and environmental cues. Thus far, our knowledge of the maize membrane-trafficking system is still limited. In this
Chunyan Zheng, Yin Yu, Guiling Deng, Hanjie Li, Faqiang Li   +4 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Controlling Cargo Trafficking in Multicomponent Membranes [PDF]

Nano Letters, 2018
Biological membranes typically contain a large number of different components dispersed in small concentrations in the main membrane phase, including proteins, sugars, and lipids of varying geometrical properties. Most of these components do not bind the cargo.
Curk, Tine, Wirnsberger, Peter, Dobnikar, Jure, Frenkel, Daan, Šarić, Anđela   +4 more
openaire   +4 more sources

Phosphatidylinositol 3-monophosphate is involved in Toxoplasma apicoplast biogenesis [PDF]

, 2011
Apicomplexan parasites cause devastating diseases including malaria and toxoplasmosis. They harbour a plastid-like, non-photosynthetic organelle of algal origin, the apicoplast, which fulfils critical functions for parasite survival.
Henri J Vial, Dubremetz, J.-F., Payrastre, B., Merezegue, F., Montcourrier, Philippe, Merezegue, Fabrice, Jean-François Dubremetz, Tawk, Lina, Payrastre Bernard, Chicanne Gaëtan, Payrastre, Bernard, Roy Christian, Philippe Montcourrier, Lebrun Maryse, Vial, H.J., Vial Henri J., Véronique Richard, Henri J. Vial, Roy, C., Dubremetz Jean-François, Markus Meissner, Lebrun, M., Chicanne, G., Kai Wengelnik, Wengelnik Kai, Christian Roy, Wengelnik, Kai, Lina Tawk, Chicanne, Gaëtan, Montcourrier Philippe, Lebrun, Maryse, Bernard Payrastre, Vial, Henri, Roy, Christian, Fabrice Merezegue, Richard, V., Meissner, M., Meissner Markus, Richard Véronique, Tawk, L., Meissner, Markus, Gaëtan Chicanne, Maryse Lebrun, Tawk Lina, Merezegue Fabrice, Dubremetz, Jean-François, Wengelnik, K., Montcourrier, P., Richard, Véronique   +48 more
core   +1 more source

Trafficking of central opioid receptors and descending pain inhibition

Molecular Pain, 2007
The delta-opioid receptor (DOR) belongs to the superfamily of G-protein-coupled receptors (GPCRs) with seven transmembrane domains, and its membrane trafficking is regulated by intracellular sorting processes involving its C-tail motifs, intracellular ...
Pan Zhizhong Z, Bie Bihua
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking [PDF]

, 2009
We have previously reported that galectin-4, a tandem repeat-type galectin, regulates the raft-dependent delivery of glycoproteins to the apical brush border membrane of enterocyte-like HT-29 cells.
Huet, Guillemette, Stechly, Laurence, André, Sabine, Seuningen, Isabelle Van, van Seuningen, Isabelle, Gabius, Hans-Joachim, Morelle, Willy, Michalski, Jean-Claude, Porchet, Nicole   +8 more
core   +1 more source

Establishment of a synchronized tyrosinase transport system revealed a role of Tyrp1 in efficient melanogenesis by promoting tyrosinase targeting to melanosomes

Scientific Reports
Tyrosinase (Tyr) is a key enzyme in the process of melanin synthesis that occurs exclusively within specialized organelles called melanosomes in melanocytes.
Hikari Nakamura, Mitsunori Fukuda
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source