Results 131 to 140 of about 917,628 (315)

Multiple novel membrane proteins involve phthalate ester degradation in Rhodococcus sp. AH-ZY2

Applied and Environmental Microbiology
Phthalate esters (PAEs) are ubiquitous in the environment, and their microbial metabolism is associated with transport proteins. In this study, multiple novel membrane proteins were identified, revealing their pivotal role in PAEs degradation.
Zhengyu Hou, Hejuan Pan, Shihan Wang, Yulin Li, Yang Yu, Pei Qiao, Haixia Wang, Weihong Zhong   +7 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Transport of sphingomyelin to the cell surface is inhibited by brefeldin A and in mitosis, where C6-NBD-sphingomyelin is translocated across the plasma membrane by a multidrug transporter activity

, 1997
Sphingomyelin is a major lipid of the mammalian cell surface. The view that sphingomyelin, after synthesis in the Golgi lumen, reaches the outer leaflet of the plasma membrane on the inside of carrier vesicles has been challenged by inconsistencies in ...
van Meer, G., Thielemans, M., Giudici, M.L., van Helvoort, A., Universiteit Utrecht, Dep Scheikunde, Membrane Enzymology   +6 more
core  

Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel

Cellular Physiology and Biochemistry, 2020
Rajesh Bhardwaj, Bartłomiej S. Augustynek, Ebru Ercan-Herbst, Palanivel Kandasamy, Matthias Seedorf, Christine Peinelt, Matthias A. Hediger   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Intracellular Membrane Transport in Vascular Endothelial Cells. [PDF]

Int J Mol Sci, 2023
Mironov AA, Mironov A, Sanavio B, Krol S, Beznoussenko GV.   +4 more
europepmc   +1 more source

Transport Across Membranes

Accounts of Chemical Research, 2013
Matile Stefan, Fyles Tom
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Impact of the surface energy of particulate foulants on membrane fouling

, 2016
Foulant-foulant and foulant-membrane interfacial interactions play an important role in dictating the extent of fouling. In order to understand the impact of the surface energy of particulate foulants on the fouling extent, the direct observation through
Cornelissen, Emile R., Fane, Anthony G., Ullah, Asmat, Chew, Jia Wei, Fane, Anthony Gordon, Akhondi, Ebrahim, Honciuc, Andrei, Tanudjaja, Henry Jonathan, Tanudjaja, Henry J., Zamani, Farhad, Cornelissen, Emile, Fane, Anthony G, Tanudjaja, Henry J   +12 more
core   +1 more source