Results 51 to 60 of about 4,164,744 (312)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175

eLife, 2022
Structures of the human lysosomal K+ channel transmembrane protein 175 (TMEM175) in open and closed states revealed a novel architecture lacking the canonical K+ selectivity filter motif present in previously known K+ channel structures.
SeCheol Oh, Fabrizio Marinelli, Wenchang Zhou, Jooyeon Lee, Ho Jeong Choi, Min Kim, José D Faraldo-Gómez, Richard K Hite   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Mechanism of Na+-dependent citrate transport from the structure of an asymmetrical CitS dimer

eLife, 2015
The common human pathogen Salmonella enterica takes up citrate as a nutrient via the sodium symporter SeCitS. Uniquely, our 2.5 Å x-ray structure of the SeCitS dimer shows three different conformations of the active protomer.
David Wöhlert, Maria J Grötzinger, Werner Kühlbrandt, Özkan Yildiz   +3 more
doaj   +1 more source

Dense Granule Protein GRA64 Interacts with Host Cell ESCRT Proteins during Toxoplasma gondii Infection

mBio, 2022
The intracellular parasite Toxoplasma gondii adapts to diverse host cell environments within a replicative compartment that is heavily decorated by secreted proteins.
Joshua Mayoral, Rebekah B. Guevara, Yolanda Rivera-Cuevas, Vincent Tu, Tadakimi Tomita, Julia D. Romano, Leslie Gunther-Cummins, Simone Sidoli, Isabelle Coppens, Vernon B. Carruthers, Louis M. Weiss   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Removal of adsorbing estrogenic micropollutants by nanofiltration membranes:Part B-Model development [PDF]

, 2013
Removal of estrone (E1) and estradiol (E2) by nanofiltration membranes at neutral pH is carried out both by size exclusion and adsorption. Size exclusion is dependent on the solute to pore radius ratio and the hormone-membrane affinity. It has been shown
Schaefer, AndreaI., Foucher, Matthieu, Semiao, Andrea J. C.   +2 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

From “Black Box” to a Real Description of Overall Mass Transport through Membrane and Boundary Layers

Membranes, 2019
The “black box” model defines the enhancement, the polarization modulus, and the intrinsic enhancement, without knowing the transport mechanism in the membrane.
Endre Nagy, Márta Vitai
doaj   +1 more source