Results 111 to 120 of about 1,758,715 (411)

Endocytic proteins drive vesicle growth via instability in high membrane tension environment [PDF]

, 2015
Clathrin-mediated endocytosis (CME) is a key pathway for transporting cargo into cells via membrane vesicles. It plays an integral role in nutrient import, signal transduction, neurotransmission and cellular entry of pathogens and drug-carrying nanoparticles.
arxiv   +1 more source

VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles [PDF]

, 1992
In simple epithelial cells, apical and basolateral proteins are sorted into separate vesicular carriers before delivery to the appropriate plasma membrane domains.
Dupree, P., Kellner, R., Kurzchalia, T. V., Lehnert, M., Parton, R. G., Simons, K., Virta, H.   +6 more
core   +3 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Ribonucleoparticle-independent transport of proteins into mammalian microsomes [PDF]

, 1990
There are at least two different mechanisms for the transport of secretory proteins into the mammalian endoplasmic reticulum. Both mechanisms depend on the presence of a signal peptide on the respective precursor protein and involve a signal peptide ...
Cobet, Werner W. E., Jung, Christian, Klappa, Peter, Morel, F., Müller, Günter, Schlenstedt, Gabriel, Wiech, Hans, Zimmermann, M., Zimmermann, Richard   +8 more
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Analysis of outer membrane vesicle associated proteins isolated from the plant pathogenic bacterium Xanthomonas campestris pv. campestris

BMC Microbiology, 2008
Background Outer membrane vesicles (OMVs) are released from the outer membrane of many Gram-negative bacteria. These extracellular compartments are known to transport compounds involved in cell-cell signalling as well as virulence associated proteins, e ...
Niehaus Karsten, Vorhölter Frank-Jörg, Sidhu Vishaldeep K, Watt Steven A   +3 more
doaj   +1 more source

Relaxing the aquaporin crystal structure in a membrane with surface vibrational spectroscopy [PDF]

arXiv, 2019
High-resolution structural information on membrane proteins is essential for understanding cell biology and for structure-based design of new medical drugs and drug delivery strategies. X-ray diffraction (XRD) can provide {\AA}ngstrom-level information about the structure of membrane proteins. Ideally protein structures should be solved in environments
arxiv  

Ca2+-induced fusion of Golgi-derived secretory vesicles isolated from rat liver [PDF]

, 1975
During the transport of plasma proteins from the cytoplasma of hepatocytes to the extracellular fluid srnall vesicles may act as shuttles between the Golgi complex and the plasma membrane.
Ahkong, Berger, Bergeron, Branton, Dahl, Dempsey, Ehrenreich, Ekholm, Farquhar, G. Dahl, Ichikawa, Lowry, M. Gratzl, Moor, Portzehl, Rasmussen, Röhlich, Schudt, Schwab-Stey   +18 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Glycosylphosphatidylinositol-anchored proteins: Membrane organization and transport

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016
Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are a class of membrane proteins containing a soluble protein attached by a conserved glycolipid anchor to the external leaflet of the plasma membrane. In polarized epithelial cells, GPI-APs are predominantly sorted to the apical surface in the trans-Golgi network (TGN) by clustering in ...
Zurzolo C., Simons K.
openaire   +4 more sources