Results 121 to 130 of about 1,758,715 (411)

Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge [PDF]

open access: yesScience, 2018
How lipopolysaccharides bridge the gap The outer membrane of Gram-negative bacteria is composed of lipopolysaccharide, a large glycolipid that prevents drugs from entering the cells. Disrupting lipopolysaccharide assembly hypersensitizes bacteria to antibiotics. Sherman et al.
David J. Sherman   +7 more
openaire   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Distinct N-terminal regions of the exomer secretory vesicle cargo Chs3 regulate its trafficking itinerary

open access: yesFrontiers in Cell and Developmental Biology, 2014
Cells transport integral membrane proteins between organelles by sorting them into vesicles. Cargo adaptors act to recognize sorting signals in transmembrane cargos and to interact with coat complexes that aid in vesicle biogenesis. No coat proteins have
Amanda M. Weiskoff   +1 more
doaj   +1 more source

Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores

open access: yesNature Communications, 2020
The contribution of central and peripheral channels of nuclear pores to transport of transmembrane proteins is unclear. Here the authors show that most inner nuclear membrane proteins use only peripheral channels, but some extend nuclear localization ...
Krishna C. Mudumbi   +9 more
doaj   +1 more source

Small hydrophobic viral proteins involved in intercellular movement of diverse plant virus genomes

open access: yesAIMS Microbiology, 2020
Most plant viruses code for movement proteins (MPs) targeting plasmodesmata to enable cell-to-cell and systemic spread in infected plants. Small membrane-embedded MPs have been first identified in two viral transport gene modules, triple gene block (TGB)
Sergey Y. Morozov, Andrey G. Solovyev
doaj   +1 more source

Correlated diffusion of membrane proteins and their effect on membrane viscosity [PDF]

open access: yes, 2008
We extend the Saffman theory of membrane hydrodynamics to account for the correlated motion of membrane proteins, along with the effect of protein concentration on that correlation and on the response of the membrane to stresses. Expressions for the coupling diffusion coefficients of protein pairs and their concentration dependence are derived in the ...
arxiv   +1 more source

Membrane association and remodeling by intraflagellar transport protein IFT172 [PDF]

open access: yesNature Communications, 2018
AbstractThe cilium is an organelle used for motility and cellular signaling. Intraflagellar transport (IFT) is a process to move ciliary building blocks and signaling components into the cilium. How IFT controls the movement of ciliary components is currently poorly understood. IFT172 is the largest IFT subunit essential for ciliogenesis.
Esben Lorentzen   +9 more
openaire   +6 more sources

Mitochondrial protein import [PDF]

open access: yes, 1994
The transport of nuclear-encoded proteins from the cytosol into mitochondria is mediated by targeting (signal) sequences present on precursor forms.
Neupert, Walter, Schwarz, Elisabeth
core   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

The Road not Taken: Less Traveled Roads from the TGN to the Plasma Membrane

open access: yesMembranes, 2015
The trans-Golgi network functions in the distribution of cargo into different transport vesicles that are destined to endosomes, lysosomes and the plasma membrane.
Anne Spang
doaj   +1 more source

Home - About - Disclaimer - Privacy